SMAC Mimetic
A SMAC mimetic and pharmaceutical compositions thereof and methods of use.
1. A method of treating cancer in a mammal in need thereof that comprises administering to the mammal an effective amount of Compound 15 of the following formula:
where R5 is —CH 2 CH 3 , or a pharmaceutically acceptable salt thereof, in combination with a second cancer therapy that is chemotherapy.
2. The method of claim 1 wherein the cancer is ovarian cancer.
3. The method of claim 1 wherein the chemotherapy comprises administration of a platinum containing DNA modifying agent.
4. The method of claim 2 wherein the chemotherapy comprises administration of a platinum containing DNA modifying agent.
5. The method of claim 3 wherein the chemotherapy comprises administration of carboplatin, cisplatin, or oxaliplatin.
6. The method of claim 4 wherein the chemotherapy comprises administration of carboplatin, cisplatin, or oxaliplatin.
7. The method of claim 1 wherein the chemotherapy comprises administration of carboplatin.
8. The method of claim 2 wherein the chemotherapy comprises administration of carboplatin.
9. A method for inducing apoptosis in a cancer cell comprising contacting the cell with Compound 15 of the following formula:
where R5 is —CH 2 CH 3 , or a pharmaceutically acceptable salt thereof, and also contacting the cell with a second cancer therapy that is chemotherapy.
10. The method of claim 9 wherein the cancer cell is an ovarian cancer cell.
11. The method of claim 9 wherein the chemotherapy comprises administration of a platinum containing DNA modifying agent.
12. The method of claim 10 wherein the chemotherapy comprises administration of a platinum containing DNA modifying agent.
13. The method of claim 9 wherein the chemotherapy comprises administration of carboplatin, cisplatin, or oxaliplatin.
14. The method of claim 9 wherein the chemotherapy comprises administration of carboplatin.
15. The method of claim 10 wherein the chemotherapy comprises administration of carboplatin.
16. The method of claim 1 wherein Compound 15 is administered by intravenous infusion.
17. The method of claim 1 wherein Compound 15 is administered by intravenous bolus.