Bioerodible matrix for tissue involvement
Disclosed herein are polyurethane polymer matrices with a porosity of from about 20 microns to about 90 microns that are useful in promoting closure and protection of incision sites; supporting the lower pole position of breast implants; and providing a partial or complete covering of breast implants to provide a beneficial interface with host tissue and to reduce the potential for malpositioning or capsular contracture. The disclosed matrices can be seeded with mammalian cells.
1. A medical implant comprising:
a breast prosthesis; and
a matrix on said breast prosthesis, the matrix comprising a resorbable or bioerodible polymer component and a cellular component, wherein the polymer component comprises polycaprolactone soft segments having an amorphous rubbery phase, the matrix having a porosity conducive to cell growth and capable of providing a beneficial interface between the prosthesis and host tissue to enhance biocompatibility and reducing the potential for malpositioning or capsular contracture.
2. The implant of claim 1 wherein the cellular component comprises stem cells.
3. The implant of claim 1 wherein the cellular component comprises adipose cells.
4. The implant of claim 1 wherein the cellular component comprises stem cells and adipose cells.
5. The implant of claim 1 wherein the matrix forms at least a partial covering on said breast prosthesis.
6. The implant of claim 1 wherein the matrix forms a complete covering of said breast prosthesis.
7. The implant of claim 1 wherein the matrix has a pore size diameter of about 10 to about 1000 microns.
8. The implant of claim 1 wherein the matrix has a pore size diameter of from about 20 to about 90 microns.