IP Library Granted Patent US 10,220,205
Granted Patent B2
US 10,220,205 · App. 15/380,779 · Granted Mar 5, 2019

Systems and methods that provide electrical stimulation to a nerve to reduce a reflex that affects a bodily function

Inventors: Narendra Bhadra (Chesterland, OH); Kenneth J. Gustafson (Shaker Heights, OH); Jaime L. McCoin (Pittsburgh, PA)
Assignee: CASE WESTERN RESERVE UNIVERSITY
A61N1/36007A61N1/36014A61N1/36017A61N1/36057A61N1/36171A61N1/36178
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Quick Facts
Patent No.
US 10,220,205
App. No.
15/380,779
Granted
Mar 5, 2019
Kind
B2
Abstract

One aspect of the present disclosure relates to a system for electrical stimulation. A waveform generator can be configured to generate an electrical waveform. An electrode can be electrically coupled to the waveform generator and configured to deliver the electrical waveform to a nerve to reduce at least one reflex that affects a bodily function.

Claims (9)

1. A method comprising the steps of:

generating, by a waveform generator, an electrical waveform comprising cycles of an on time that comprises a patterned electrical waveform, comprising a base waveform and a burst waveform occupying 75% of the base waveform, and an off time; and

delivering, by an electrode coupled to the waveform generator, the electrical waveform to a dermatome of a nerve comprising afferent nerve fibers of the subject to stimulate the afferent nerve fibers to suppress a urethral reflex that impedes urine flow and affects a bodily function.

2. The method of claim 1 , wherein the electrode is a surface electrode or a subcutaneous electrode.

3. The method of claim 1 , wherein the bodily function comprises voiding the urinary bladder.

4. The method of claim 3 , further comprising stimulating, by a bladder driver, a second nerve to activate the urinary bladder to facilitate the voiding when the urethral reflexes are reduced.

5. The method of claim of claim 1 , wherein the nerve is at least one of a peripheral nerve, a sacral spinal cord nerve, a sacral root nerve, a thoracic spinal nerve, and a lumbar spinal cord nerve.

6. The method of claim 4 , further comprising applying, by the bladder driver, electrical stimulation to at least one of a sacral root, a bladder efferent nerve, and an afferent-mediated peripheral nerve to activate the urinary bladder for voiding.

7. The method of claim 1 , wherein the nerve is a sacral afferent nerve.

Assignments (1)
CONFIRMATORY LICENSE Recorded Jun 8, 2018
From: CASE WESTERN RESERVE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 046327/0327 →
Continuity (3)
Division 14287769 · May 27, 2014
Provisional Application 61827024 · May 24, 2013
Related Publication 20170095663A1 · Apr 6, 2017
Cited By (6)
US 12,280,256 US 12,285,611 US 12,337,173 US 12,390,645 US 12,397,156 US 12,558,547