Oral care compositions and methods of use
This invention relates to oral care compositions comprising arginine, zinc citrate and zinc oxide, and an orally acceptable carrier, as well as to methods of using and of making these compositions.
1. An oral care buffering composition comprising:
a. a basic amino acid in free or salt form wherein the amino acid is arginine;
b. zinc oxide and zinc citrate; and
c. an orally acceptable carrier,
wherein the oral care composition provides a buffering effect against acidic conditions in the oral cavity following acid challenge or sucrose challenge, wherein the buffering effect is greater than a corresponding buffering effect of compositions comprising arginine, zinc oxide or zinc citrate alone,
wherein the composition is configured to be maintained at a pH over 7.0 when challenged in an acidic aqueous solution with 0.01M aqueous HCl in an amount of about 60% v/v based on the total volume of the solution.
2. The oral care composition of claim 1 , wherein the composition maintains a pH over 5.0 when challenged in an acidic aqueous solution with a cola beverage in an amount of about 90% v/v based on the total volume of the solution.
3. The oral care composition of claim 1 , wherein the composition maintains a pH over 3.9 when challenged in an acidic aqueous solution with a cola beverage in an amount of about 90% v/v based on the total volume of the solution.
4. The oral care composition of claim 1 , wherein the composition maintains a pH over 3.0 when challenged in an acidic aqueous solution with a cola beverage in an amount of about 90% v/v based on the total volume of the solution.
5. The oral care composition of claim 1 , wherein the composition maintains a pH over 5.5 when challenged in an acidic aqueous solution with a cola beverage in an amount of about 80% v/v based on the total volume of the solution.
6. The oral care composition of claim 1 , wherein the composition maintains a pH over 4.0 when challenged in an acidic aqueous solution with orange juice in an amount of about 55% v/v based on the total volume of the solution.
7. The oral care composition of claim 1 , wherein the composition maintains a pH over 6.0 when challenged in an acidic aqueous solution with orange juice in an amount of about 33% v/v based on the total volume of the solution.
8. The oral care composition of claim 1 , wherein the composition maintains a pH over 5.0 when challenged in an acidic aqueous solution with orange juice in an amount of about 33% v/v based on the total volume of the solution.
9. The oral care composition of claim 1 , wherein the composition maintains a pH over 8.0 when challenged in an acidic aqueous solution with 0.01M aqueous HCl in an amount of about 60% v/v based on the total volume of the solution.
10. The oral care composition of claim 1 , wherein the composition maintains a pH over 7.0 6 hours after sucrose challenge.
11. The oral care composition of claim 1 , wherein the composition maintains a pH over 8.0 6 hours after sucrose challenge.
12. The oral care composition of claim 1 , wherein the composition maintains a pH over 9.0 6 hours after sucrose challenge.
13. The oral care composition of claim 1 , wherein the composition maintains a pH over 7.0 24 hours after sucrose challenge.
14. The oral care composition of claim 1 , wherein the composition maintains a pH over 8.0 24 hours after sucrose challenge.
15. The oral care composition of claim 1 , wherein the composition maintains a pH over 9.0 24 hours after sucrose challenge.
16. The oral care composition of claim 1 , wherein the arginine has the L-configuration.
17. The oral care composition of claim 1 wherein the amino acid is arginine from about 1.5 wt. %.
18. The oral care composition of claim 1 , wherein the zinc citrate is in an amount of about 0.5 wt % and zinc oxide is present in an amount of about 1.0% based on the weight of the oral care composition.