Hypochlorite formulations for wound healing
A formulation is disclosed for use in wound healing. The formulation may include hypochlorous acid, a silicone polymer or blend thereof, sodium phosphate, hydrochloric acid, and sodium magnesium silicate. Methods of using and making the wound healing formulation are also disclosed.
1. A method of treating a burn in a subject afflicted with a burn, the method comprising:
applying to a burn a therapeutically effective amount of a formulation consisting of:
an electrolyzed saline solution having a salt concentration between 0.1% and 1% by weight, hypochlorite present in an amount of between 0.6 and 1% w/v, hypochlorous acid, dissolved oxygen, chlorine, hydrogen gas, hydrogen peroxide, hydrogen ions, hypochloride, ozone, activated hydrogen ions, chloride ions, hydroxides, singlet oxygen, *OCl, *HO − , and superoxides of *O 2 — and HO 2 ;
a buffer, wherein the formulation has a pH ranging from 6.7 to 7.5;
sodium magnesium silicate; and
dimethicone,
wherein the formulation has an osmolality measurement ranging from about 22 mOsm/kg to about 54 mOsm/kg; and
allowing the formulation to absorb into the burn, thereby treating the burn.
2. The method of claim 1 , wherein applying comprises topically administering the formulation to the burn.
3. The method of claim 1 , wherein the formulation is an ointment, cream, spray, gel, lotion, or solution.
4. The method of claim 1 , wherein the formulation is applied to the burn at least once daily.
5. The method of claim 1 , wherein the formulation is applied to the burn three times a day.
6. The method of claim 1 , wherein a rate of healing of the burn is accelerated as compared to a rate of healing of a non-treated burn.
7. The method of claim 1 , wherein the therapeutically effective amount is an amount effective to accelerate burn healing, promote burn closure, or cause burn regression.
8. The method of claim 1 , wherein the applying the formulation reduces, attenuates, or prevents bacterial growth or infection in the burn.
9. The method of claim 1 , wherein the buffer is in an amount of about 0.2% w/v, wherein the sodium magnesium silicate is in an amount of about 3.25% w/v, and wherein the dimethicone is in an amount of about 5.0% w/v.
10. The method of claim 1 , wherein the buffer is an acetate, an ascorbate, a carbonate, a phosphate, a citrate, or an organic based buffer.
11. The method of claim 1 , wherein the buffer comprises sodium phosphate monobasic.
12. A system for healing a burn, comprising:
a wound dressing material having a therapeutically effective amount of a formulation applied thereto, wherein the wound is a burn,
wherein the formulation consists of:
an electrolyzed saline solution having a salt concentration between 0.1% and 1% by weight, hypochlorite present in an amount of between 0.6 and 1% w/v, hypochlorous acid, dissolved oxygen, chlorine, hydrogen gas, hydrogen peroxide, hydrogen ions, hypochloride, ozone, activated hydrogen ions, chloride ions, hydroxides, singlet oxygen, *OCl, *HO − , and superoxides of *O 2 — and HO 2 ;
a buffer present in an amount of about 0.2% w/v, wherein the formulation has a pH ranging from 6.7 to 7.5;
sodium magnesium silicate; and
dimethicone,
wherein the formulation has an osmolality measurement ranging from about 22 mOsm/kg to about 54 mOsm/kg.
13. The system of claim 12 , wherein the wound dressing material is a bandage, a wipe, a gauze, a sponge, a mesh, or an absorbent wound dressing material.
14. The system of claim 12 , wherein the hypochlorite is in an amount of about 0.6% w/v, wherein the buffer is in an amount of about 0.2% w/v, wherein the sodium magnesium silicate is in an amount of about 3.25% w/v, and wherein the dimethicone is in an amount of about 5.0% w/v.
15. The method of claim 1 , wherein the burn is a thermal burn, a radiation burn, or a chemical burn.
16. The method of claim 1 , wherein the formulation is applied to a wound dressing material prior to application to the burn.
17. A method of treating a burn on an individual, the method comprising:
topically applying to the burn a therapeutically effective amount of a formulation consisting of:
an electrolyzed saline solution having a salt concentration between 0.1% and 1% by weight, hypochlorite present in an amount of about 0.6% w/v, hypochlorous acid, dissolved oxygen, chlorine, hydrogen gas, hydrogen peroxide, hydrogen ions, hypochloride, ozone, activated hydrogen ions, chloride ions, hydroxides, singlet oxygen, *OCl, *HO − , and superoxides of *O 2 — and HO 2 ;
sodium phosphate present in an amount of about 0.2% w/v, wherein the formulation has a pH ranging from 6.7 to 7.5;
sodium magnesium silicate present in an amount of about 3.25% w/v; and
dimethicone present in an amount of about 5% w/v,
wherein the formulation has an osmolality measurement ranging from about 22 mOsm/kg to about 54 mOsm/kg; and
allowing the formulation to absorb into the burn, thereby treating the burn.
18. The method of claim 17 , wherein applying the formulation to the burn accelerates healing of the burn.
19. The method of claim 1 , wherein the therapeutically effective amount of the formulation is in a range from about 0.1 g to about 1 g.
20. The method of claim 1 , wherein the therapeutically effective amount of the formulation is in an amount of about 0.4 g.