Drug delivery implants
An orthopedic implant includes an internal fixation device. The internal fixation device includes: an exterior surface; a threaded section including a reservoir and at least one threaded section channel fluidly communicating the reservoir with the exterior surface, each threaded section channel having an interior diameter and a length which is greater than the interior diameter; a head including a head channel fluidly communicating the reservoir with an exterior surface of the head, a channel diameter of the head channel being respectively larger than a largest interior diameter of each threaded section channel, the channel diameter of the head channel being the same as a large interior diameter of the reservoir; and a continuously tapering inner surface between the head channel and the reservoir.
1. An orthopaedic implant, comprising:
an internal fixation device, said internal fixation device including:
an exterior surface;
a threaded section including a reservoir and at least one threaded section channel fluidly communicating said reservoir with said exterior surface of said internal fixation device, each threaded section channel having an interior diameter and a length which is greater than said interior diameter;
a head including a head channel fluidly communicating said reservoir with an exterior surface of said head, a channel diameter of said head channel being respectively larger than a largest interior diameter of each threaded section channel, said channel diameter of said head channel being the same as a large interior diameter of said reservoir, said head defining a head diameter that is greater than a threaded section diameter of the threaded section; and
a continuously tapering, in one direction, inner surface between said head channel and said reservoir.
2. The orthopaedic implant according to claim 1 , wherein said internal fixation device is a bone screw, and wherein said at least one threaded section channel communicates said reservoir with said exterior surface of said bone screw and thereby convey at least one therapeutic agent from said reservoir to said exterior surface of said bone screw.
3. The orthopaedic implant according to claim 1 , wherein said internal fixation device includes only one said reservoir.
4. The orthopaedic implant according to claim 1 , wherein said reservoir is refillable.
5. The orthopaedic implant according to claim 1 , wherein said internal fixation device comprises at least one of polyetheretherketone (PEEK), polyetherketone (PEK), polyaryletherketone (PAEK), polyethylene, polylactic acid (PLA), and polyglycolic acid (PGA).
6. The orthopaedic implant according to claim 1 , wherein said threaded section includes at least one thread comprising at least one of a polymer, a reinforced polymer, and a metal.
7. The orthopaedic implant according to claim 1 , further comprising a second reservoir in fluid communication with said reservoir.
8. The orthopaedic implant according to claim 7 , wherein said second reservoir is in fluid communication with said reservoir via said head channel.
9. The orthopaedic implant according to claim 7 , wherein said reservoir is at least partially filled with a first therapeutic agent and said second reservoir is at least partially filled with at least one of said first therapeutic agent and a second therapeutic agent different from said first therapeutic agent.
10. The orthopaedic implant according to claim 1 , wherein said internal fixation device includes a plurality of threaded section channels including at least one threaded section channel on a first side of said reservoir and at least one threaded section channel on a second side of said reservoir opposite said first side.