Device and method for applying a pharmaceutical fluid
A device and method for applying a pharmaceutical fluid comprising a hollow cylindrical body, which surrounds a channel that extends through the body from a proximal body end to a distal body end of the body, wherein an outer surface of the body has at least partially an external thread, and has a connecting element arranged at the proximal body end, via which a proximal channel end of the channel can be reversibly connected in terms of fluid conduction to a reservoir for the pharmaceutical fluid.
1 . A device for applying a pharmaceutical fluid comprising:
a hollow cylindrical body, which surrounds a channel that extends through the body from a proximal body end to a distal body end of the body,
wherein an outer surface of the body has at least partially an external thread, and comprising a connecting element arranged at the proximal body end, via which a proximal channel end of the channel can be reversibly connected in terms of fluid conduction to a reservoir for the pharmaceutical fluid,
wherein a check valve that is arranged in the channel and is fluid-impermeable in a direction of the proximal channel end, and a sealing element arranged in the channel distal to the check valve, which closes a distal channel end of the channel in terms of fluid conduction and which has a gap that can be reversibly opened in terms of fluid conduction when pressure is applied to the pharmaceutical fluid from the direction of the proximal channel end, such that the pharmaceutical fluid can be applied from the distal channel end.
2 . The device according to claim 1 , wherein the gap reversibly opens in terms of fluid conduction upon the application of pressure greater than 5 N/cm 2 .
3 . The device according to claim 1 , wherein the check valve is a ball check valve comprising a ball and a restoring element.
4 . The device according to claim 3 , wherein the restoring element and the sealing element are configured in one piece.
5 . The device according to claim 1 , wherein a filter element is arranged in the channel.
6 . The device according to claim 5 , wherein the filter element is arranged in the channel proximally to the check valve.
7 . The device according to claim 5 , wherein the filter element is a microporous filter plate.
8 . The device according to claim 7 , wherein the microporous filter plate has pores with an average pore diameter of less than 40 μm.
9 . The device according to claim 1 , wherein a hollow cylindrical sleeve is arranged in the channel distally to the sealing element, in order to prevent the discharging of the sealing element from the distal channel end during the application of the pharmaceutical fluid.
10 . The device according to claim 1 , wherein the proximal channel end is designed to be polygonal, and the connecting element is equipped with a polygonal connecting element section, in order to reversibly connect in terms of fluid conduction the connecting element to the proximal channel end by inserting the connecting element section into the proximal channel end.
11 . The device according to claim 10 , wherein the proximal channel end has a larger axial extension than the connecting element section, such that, after removal of a part of the proximal channel end, the connecting element can be reversibly connected in terms of fluid conduction to a part of the proximal channel end remaining on the device by inserting the connecting element section into the remaining proximal channel end.
12 . The device according to claim 1 , wherein the body comprises a metal and/or a polymer.
13 . A method for applying a pharmaceutical fluid by means of a device, said device comprising:
a hollow cylindrical body, which surrounds a channel that extends through the body from a proximal body end to a distal body end of the body,
wherein an outer surface of the body has at least partially an external thread, and comprising a connecting element arranged at the proximal body end, via which a proximal channel end of the channel can be reversibly connected in terms of fluid conduction to a reservoir for the pharmaceutical fluid,
wherein a check valve that is arranged in the channel and is fluid-impermeable in a direction of the proximal channel end, and a sealing element arranged in the channel distal to the check valve, which closes a distal channel end of the channel in terms of fluid conduction and which has a gap that can be reversibly opened in terms of fluid conduction when pressure is applied to the pharmaceutical fluid from the direction of the proximal channel end, such that the pharmaceutical fluid can be applied from the distal channel end;
said method for applying the pharmaceutical fluid by means of the device, comprising the following steps:
a. Implanting of the device;
b. Connecting in terms of fluid conduction of the device to a reservoir for the pharmaceutical fluid;
c. Building up of a conveyance pressure on the pharmaceutical fluid from the direction of the proximal channel end of greater than 5 N/cm 2 ;
d. Opening in terms of fluid conduction of the gap in the sealing element by the action of the conveyance pressure;
e. Dispensing of the pharmaceutical fluid from the gap that is open in terms of fluid conduction;
f. Closing in terms of fluid conduction of the gap by reducing the conveyance pressure to 5 N/cm 2 or less.