System and stent for repairing endovascular defects and methods of use
Disclosed are endovascular stents in which a portion of the stents have a bioactive coating for promoting repair of damaged vessels, systems comprising the stents, and methods of using the stents to promote occlusion of aneurysms and/or repair damaged vessels.
1. A coating for improving cellular adhesion, differentiation, and proliferation for use with stents, the coating comprising:
a layer of a magnetic material deposited on a portion of an outer surface of the stent, wherein the magnetic material comprises a bacterial nanocellulose polymer impregnated with a magnetic metal material; and
an ion-beam nanostructured biocompatible layer deposited on the layer of magnetic material.
2. The coating of claim 1 , wherein the ion-beam nanostructured biocompatible layer comprises gold.
3. The coating of claim 1 , wherein the ion-beam nanostructured biocompatible layer is produced during irradiation by ion sputtering.
4. The coating of claim 1 , wherein the magnetic metal material is nickel.
5. The coating of claim 1 , wherein the magnetic material comprises endothelial cells.
6. The coating of claim 1 further comprising a plurality of nanoscale particles embedded in the coating to provide radiation-enhanced tomography for visualization of a stent surface.
7. The coating of claim 1 further comprising a chromium layer positioned between the layer of magnetic material and the outer surface of the stent.
8. The coating of claim 1 further comprising a bioactive layer formed on the ion-beam nanostructured biocompatible layer.
9. The coating of claim 8 , wherein the bioactive layer comprises porcine coronary smooth muscle (PCSM).
10. A coating for improving cellular adhesion, differentiation, and proliferation for use with a stent, the coating comprising:
a chromium layer deposited on an outer surface of the stent;
a layer of a magnetic material deposited on a portion of the chromium layer, wherein the magnetic material comprises a polymer impregnated with a magnetic metal material;
an ion-beam nanostructured biocompatible layer deposited on the layer of magnetic material; and
a bioactive layer formed on the ion-beam nanostructured biocompatible layer.
11. The coating of claim 10 , wherein the ion-beam nanostructured biocompatible layer is produced during irradiation by ion sputtering.
12. The coating of claim 10 , wherein the magnetic metal material is nickel.
13. The coating of claim 10 , wherein the polymer is bacterial nanocellulose.
14. The coating of claim 10 , wherein the magnetic material comprises endothelial cells.
15. The coating of claim 10 further comprising a plurality of nanoscale particles embedded in the coating to provide radiation-enhanced tomography for visualization of a stent surface.
16. The coating of claim 10 , wherein the bioactive layer comprises porcine coronary smooth muscle (PCSM).