Modular surface functionalization of polyisobutylene-based materials
A polymer composite includes a functionalized polyisobutylene and an additional polyisobutylene-containing material. The functionalized polyisobutylene includes an α-lipoic acid functional group. A method for producing the polymer composite includes providing the additional polyisobutylene-containing material as a substrate having a surface, and coating the surface of the substrate with the functionalized polyisobutylene. A method for producing a coated substrate including the polymer composite includes providing a polymer combination including the functionalized polyisobutylene and the additional polyisobutylene-containing material, and depositing the polymer combination on to a substrate to thereby form the coated substrate.
1. A polymer composite comprising a functionalized polyisobutylene and an additional polyisobutylene-containing material, wherein the functionalized polyisobutylene includes an α-lipoic acid functional group.
2. The composite of claim 1 , wherein the functionalized polyisobutylene and the additional polyisobutylene-containing material are not attached by a covalent bond.
3. The composite of claim 1 , wherein the additional polyisobutylene-containing material is non-functionalized.
4. The composite of claim 1 , wherein the additional polyisobutylene-containing material is selected from the group consisting of linear polyisobutylene thermoplastic elastomers (TPEs), star polyisobutylene TPEs, and arborescent polyisobutylene TPEs.
5. The composite of claim 1 , wherein the additional polyisobutylene-containing material is an arborescent polyisobutylene-based TPE with poly(para-methyl styrene) end blocks (arbPIB-MS).
6. A coated substrate comprising the composite of claim 1 , coated on a substrate.
7. The coated substrate of claim 6 , wherein the substrate is a breast implant.
8. The coated substrate of claim 6 , wherein the composite has a protein adsorption less than 25 ng/cm 2 with respect to the protein fibrinogen.
9. The coated substrate of claim 6 , wherein the functionalized polyisobutylene forms a functionalized polyisobutylene compound layer having a thickness, wherein the thickness of the functionalized polyisobutylene compound layer is less than 1 micron.
10. The coated substrate of claim 6 , wherein the functionalized polyisobutylene forms a functionalized polyisobutylene compound layer having a thickness, wherein the thickness of the functionalized polyisobutylene compound layer is less than 20 nm.
11. The coated substrate of claim 6 , the composite having a thickness, wherein the thickness of the composite is less than 1 micron.
12. The coated substrate of claim 6 , the composite having a thickness, wherein the thickness of the composite is less than 20 nm.
13. The coated substrate of claim 6 , the composite having a surface, wherein a drug or molecule is attached to the surface of the composite.
14. A method for producing the polymer composite of claim 1 , comprising steps of providing the additional polyisobutylene-containing material as a substrate having a surface, and coating the surface of the substrate with the functionalized polyisobutylene.
15. The method of claim 14 , wherein the step of coating includes spray coating the functionalized polyisobutylene onto the surface of the substrate.
16. The method of claim 14 , wherein the step of coating includes dipping the surface of the substrate in a solution containing the functionalized polyisobutylene.
17. A method for producing a coated substrate including the polymer composite of claim 1 , comprising steps of
providing a polymer combination comprising the functionalized polyisobutylene and the additional polyisobutylene-containing material, and
depositing the polymer combination on to a substrate to thereby form the coated substrate.
18. The method of claim 17 , wherein the step of depositing is electrospraying.
19. The method of claim 17 , wherein the step of depositing is electrospinning.