Redox signaling gel formulation
Redox signaling gels are disclosed. Such gels include a composition with at least one reactive oxygen species (ROS) and a rheology modifier. Also presented herein is a process for making the gels which includes making the composition by taking the steps of purifying water to produce ultra-pure water, combining a salt to the ultra-pure water to create a salinated water, electrolyzing the salinated water at a temperature of 4.3 to 5.8° C. such that the electrolyzing is accomplished with an anode, cathode and power source such that the power source comprises a transformer and a rectifier and does not comprise a filter capacitor.
1. A composition for topical application, comprising:
a rheology modifier and an electrolyzed saline solution formulated as a gel,
the rheology modifier comprising one or more of SiO 2 , MgO, Li 2 O, sodium magnesium silicate, and Na 2 O, and
the electrolyzed saline solution comprising:
sodium at a concentration of 1000 to 1400 ppm,
chloride present at a concentration from 1200 to 1600 ppm, and
hypochlorous acid,
wherein the electrolyzed saline solution further comprises a superoxide radical present at a concentration of 94 μM, wherein at least 95% of the superoxide radical is stable over a 13 month period.
2. The composition of claim 1 , wherein the hypochlorous acid is present at a concentration of about 16 ppm to about 24 ppm or at a concentration of about 2300 ppm to about 2700 ppm.
3. The composition of claim 1 , wherein the electrolyzed saline solution further comprises a hydroxyl radical present at a concentration of 241 μM or a hydroxyl radical present at a concentration of 0 to 10 ppm.
4. The composition of claim 1 , wherein no hydroxyl radical is present in the composition.
5. The composition of claim 1 , wherein the pH of the gel is between 6 and 9.
6. The composition of claim 5 , wherein the pH of the gel is 7.6.
7. The composition of claim 1 , wherein the rheology modifier comprises SiO 2 or sodium magnesium silicate.
8. A method of treating a subject using a composition comprising redox-signaling molecules, the method comprising:
administering the composition of claim 1 to the subject.
9. A method of treating a fungal infection of a subject comprising contacting the fungal infection or an area infected with a fungus with a composition of claim 1 thereby reducing or ameliorating a fungal infection in the subject.
10. A method of reducing the presence of at least one fungus comprising contacting the at least one fungus with a composition of claim 1 , thereby reducing the presence of at least one fungus.
11. The composition of claim 1 , wherein the rheology modifier is present at a concentration of about 1% to about 2% by weight.
12. The composition of claim 1 further comprising a buffering agent.
13. The composition of claim 12 , wherein the buffering agent is present in an amount of about 0.1% to about 5% by weight.
14. The composition of claim 12 , wherein the buffering agent comprises sodium phosphate.
15. The composition of claim 1 , wherein the gel has a viscosity that ranges from about 12,000 centipoise to about 20,000 centipoise.
16. The method of claim 8 , wherein the composition is administered to the subject in an amount of 4 ounces twice daily.
17. The method of claim 9 , wherein the composition is administered to the subject in an amount of 4 ounces twice daily.
18. The method of claim 10 , wherein the composition is administered to the subject in an amount of 4 ounces twice daily.