Contact-type patch, staining method using the same, and manufacturing method thereof
The present disclosure relates to a gel-phase patch that performs a function of assisting in staining during a staining process such as a process of coming into contact with a specimen such as blood to perform a staining function of staining the specimen, a process of fixing the specimen, or a process of forming an optimal pH at a specimen stained by a staining sample. According to an aspect of the present disclosure, a contact-type staining patch includes a staining solution that reacts with a specimen and a gel receptor provided as a gel matrix of a mesh structure in which a pore that accommodates the staining solution is formed and the mesh structure prevents the staining solution in the pore from leaking or degenerating, and having a contact surface that comes into contact with the specimen to transfer some of the staining solution to the specimen.
1. A contact-type staining patch comprising:
a staining solution having a staining substance configured to react with a specimen to be inspected; and
a gel receptor provided as a gel matrix of a mesh structure in which a plurality of pores that contains the staining solution is formed and the mesh structure is configured to prevent the staining solution in the plurality of pores from leaking or degenerating, and having a contact surface that comes into contact with the specimen to transfer the staining substance to the specimen from the gel receptor, wherein the transferred staining substance reacts with the specimen,
wherein the gel receptor is provided in a form of a column having a first surface as the contact surface, a second surface facing away from the first surface and a thickness as a distance between the first surface and the second surface, and the thickness is smaller than a length of the contact surface in a first direction.
2. The contact-type staining patch of claim 1 , wherein:
the staining solution includes the staining substance configured to react with the specimen and a solvent configured to create a reaction condition of the staining substance; and
the gel receptor uses the mesh structure to maintain a reaction condition of the staining solution.
3. The contact-type staining patch of claim 1 , wherein, in a process in which the staining solution is transferred to the specimen through the contact surface, the gel receptor inhibits excessive movement of the staining solution by using the mesh structure to prevent residue from remaining at the specimen.
4. The contact-type staining patch of claim 1 , wherein the contact-type staining patch is a staining patch configured to assign a color to a specific component of the specimen, an antibody patch including an antibody that causes an antigen-antibody reaction with the specimen, or a DNA patch including a DNA probe that couples to a specific DNA sequence of the specimen.
5. The contact-type staining patch of claim 1 , wherein the staining solution includes the staining substance selected from a staining substance that directly stains the specimen, a precipitation/aggregation inducing substance that either precipitates or aggregates the specimen, a fluorescent substance that allows the specimen to form a fluorescent color, an isotope that allows the specimen to be detected with radiation, and an enzyme attached to the specimen which secretes a detectable substance.
6. The contact-type staining patch of claim 5 , wherein:
the staining solution includes an attaching substance that is coupled to the staining substance and reacts with a specific component of the specimen to be attached to the specimen; and
the attaching substance includes an antibody that causes an antigen-antibody reaction with the specimen or a DNA probe that has a sequence complementary to a specific DNA sequence of the specimen.
7. The contact-type staining patch of claim 1 , wherein:
the staining solution is provided in a liquid state; and
the gel receptor is provided as hydrogel that inhibits a leakage of the staining solution in the liquid state to the outside.
8. The contact-type staining patch of claim 1 , wherein:
the staining solution includes a first staining sample that stains a specimen and a second staining sample that stains the specimen and is different from the first staining sample; and
the part of the staining solution transferred to the specimen includes a part of the first staining sample and a part of the second staining sample.