IP Library Granted Patent US 10,052,287
Granted Patent B2
US 10,052,287 · App. 15/502,007 · Granted Aug 21, 2018

Delivery system comprising a core and a digestible polymer shell

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Quick Facts
Patent No.
US 10,052,287
App. No.
15/502,007
Granted
Aug 21, 2018
Kind
B2
Abstract

A delivery vehicle comprising a core ( 1 ) surrounded by a digestible polymer shell ( 4 ) having a melting and/or softening point above the body temperature of an animal or human, wherein said core comprises a lipid and/or lipophilic active ingredient ( 2 ) dispersed in a continuous polymer matrix ( 3 ). The delivery vehicle can be used to release lipid and/or lipophilic active ingredients, such as pharmaceuticals, nutraceuticals, supplements, traditional/herbal medicine, or combinations thereof, after a predetermined lag time following ingestion.

Claims (16)

1. A method for the preparation of a delivery vehicle, the method comprising:

adding a lipid and/or lipophilic active ingredient to a first solution and mixing the first solution with the lipid and/or lipophilic active ingredient to form a first mixture;

homogenising the first mixture;

adding a polymer matrix polymer to the homogenized first mixture to form a second mixture;

heating the second mixture until the polymer matrix polymer melts and the second mixture becomes homogeneous;

forming a shape from the homogeneous second mixture;

placing the formed shape or small droplets thereof in a second solution, the second solution comprising at least one digestible polymer of a digestible polymer shell, to form a third mixture; and

forming a shape from the third mixture and crosslinking the at least one digestible polymer of the digestible polymer shell to produce a delivery vehicle comprising a core surrounded by the digestible polymer shell having a melting and/or softening point above a body temperature of an animal or human,

wherein the core comprises the lipid and/or lipophilic active ingredient dispersed in a continuous polymer matrix of the polymer matrix polymer, and wherein the at least one digestible polymer comprised within the digestible polymer shell is a cross linked digestible biopolymer.

2. The method of claim 1 , wherein the at least one digestible polymer comprised within the digestible polymer shell is a thermally cross-linked digestible biopolymer.

3. The method of claim 1 , wherein the polymer matrix is a biopolymer matrix, and the biopolymer is selected from the group consisting of gelatine, carrageenans, pectin, alginates, agar, gellan, konjac mannan, guar gum, gellan gum, locust bean gum, and mixtures thereof.

4. The method of claim 1 , wherein the lipid and/or lipophilic active ingredient is selected from the group consisting of a pharmaceutical, a nutraceutical, a supplement, a veterinary drug, a natural/traditional medicine, a food ingredient, and mixtures thereof.

5. The method of claim 1 , wherein the lipid and/or lipophilic active ingredient is selected from the group consisting of triglycerides, phospholipids, diglycerides, monoglycerides, ceramides, glycolipids, sphingolipids, fish oil, petroselinic acid, eicosapentaenoic acid, carotenoids, phytosterols, phytosterol esters, polyphenols, cholesterol, cholesterol esters, retinol, retinol ester, and mixtures thereof.

6. The method of claim 1 , wherein the core contains an emulsifier.

7. The method of claim 1 , wherein the at least one digestible polymer comprised within the digestible polymer shell is selected from the group consisting of bovine serum albumin, (β-lactoglobulin, lactoferrin, whey protein isolate, patatin, soy protein, canola protein, pea protein, egg protein, lysozyme, pea proteins, lupin, rice protein, gluten, lysozyme, zein, and mixtures thereof.

8. The method of claim 1 , wherein the digestible polymer shell has an average mesh/pore size of <50 nm.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 16062921 PREVIOUSLY RECORDED ON REEL 049391 FRAME 0756. ASSIGNOR(S) HEREBY CONFIRMS THE PATENT NUMBER SHOULD HAVE BEEN 16062912. Recorded Jul 3, 2020
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 054082/0001 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 16062921 PREVIOUSLY RECORDED ON REEL 049391 FRAME 0756. ASSIGNOR(S) HEREBY CONFIRMS THE PATENT NUMBER SHOULD HAVE BEEN 16062912. Recorded Jul 3, 2020
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 054082/0165 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ENGLISH TRANSLATION TO SHOW THE FULL AND CORRECT NEW NAME IN SECTION 51. PREVIOUSLY RECORDED AT REEL: 049391 FRAME: 0756. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER. Recorded Jun 13, 2019
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 049853/0398 →
MERGER Recorded Jun 6, 2019
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 049391/0756 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 7, 2017
From: WOOSTER, TIMOTHY JAMES; DONATO-CAPEL, LAURENCE; SARKAR, ANWESHA; ACQUISTAPACE, SIMONE
To: NESTEC S.A.
Reel/Frame 043478/0211 →