Use of whey protein micelles and polysaccharides for improving insulin profile
View Patent ↗The present invention relates to a composition comprising polysaccharides and whey protein micelles for use in the treatment or prevention of a disorder linked to an increase in plasma postprandial insulin in a subject. The invention relates also to the non-therapeutic use of a composition comprising polysaccharides and whey protein micelles to decrease plasma postprandial insulin concentration. A further aspect of the invention is a process for forming polysaccharide-whey protein micelle complexes.
1. A method for treating a disorder linked to an increase in plasma postprandial insulin in a subject in need of same, comprising administering to the subject a composition comprising polysaccharides and whey protein micelles, wherein the polysaccharides have a negative zeta potential at a pH value in the range of 2.5 to 4.5, wherein the weight ratio of the whey protein micelles to the polysaccharide is between 30:1 and 0.8:1, and wherein the whey protein micelles are obtainable by adjusting the pH of a whey protein aqueous solution to a value between 3.0 and 8.0 and subjecting the aqueous solution to a temperature between 80 and 98° C.
2. The method according to claim 1 wherein the disorder is selected from the group consisting of diabetes; impairment of glucose metabolism; hyperinsulinemia; and insulin resistance.
3. The method according to claim 1 wherein the subject is a diabetic or pre-diabetic patient.
4. The method according to claim 1 wherein the composition is a liquid composition comprising an aqueous dispersion of polysaccharides and whey protein micelles.
5. The method according to claim 4 , wherein the protein content of the composition is between 0.1 and 22 wt. % and wherein the composition is a heat treated composition.
6. The method according to claim 1 wherein the polysaccharides and whey protein micelles are in the form of polysaccharide-whey protein micelle complexes.
7. The method according to claim 1 wherein the composition is in the form of a beverage or yoghurt.