Controlled release of caffeine
View Patent ↗The present invention relates to an edible composition having a lipid continuous phase and self-assembled structures, the composition comprising oil, phospholipids, caffeine and water. Further aspects of the invention are the use of a composition to provide controlled release of caffeine, a composition for use in the treatment or prevention of drowsiness, the non-therapeutic use of a composition to increase mental alertness, and an edible capsule.
1. An edible composition consisting of oil, between 0.1 wt. % and 30 wt. % of phospholipids, at least 0.5 wt. % of caffeine, and between 5 and 50% wt. % of water, the oil being between 25 and 80% of the total weight of the oil and the phospholipids, the oil comprises coffee oil, and the caffeine is released from the edible composition over a time period of at least 4 hours, the edible composition forming a lipid continuous phase which is liquid at 25° C., and the edible composition also forming self-assembled structures selected from the group consisting of a reversed hexagonal structure, a reversed micellar cubic structure, and combinations thereof.
2. The edible composition according to claim 1 , wherein the oil further comprises an additional essential oil selected from the group consisting of orange oil, lemon oil, mint oil, spearmint oil, peppermint oil, eucalyptus oil and combinations of these.
3. A method for treatment of drowsiness or impaired alertness, the method comprising administering to a subject in need thereof a composition consisting of oil, between 0.1 wt. % and 30 wt. % of phospholipids, at least 0.5 wt. % of caffeine, and between 5 and 50% wt. % of water, the oil being between 25 and 80% of the total weight of the oil and the phospholipids, the oil comprises coffee oil, and the caffeine is released from the composition over a time period of at least 4 hours, the edible composition forming a lipid continuous phase which is liquid at 25° C., and the edible composition also forming self-assembled structures selected from the group consisting of a reversed hexagonal structure, a reversed micellar cubic structure, and combinations thereof.
4. The method according to claim 3 , wherein the subject is elderly.
5. The method according to claim 3 , wherein the subject is a human or a pet animal.
6. A method for treatment of obesity or being overweight, the method comprising administering to a subject in need of same a composition consisting of oil, between 0.1 wt. % and 30 wt. % of phospholipids, at least 0.5 wt. % of caffeine, and between 5 and 50% wt. % of water, the oil being between 25 and 80% of the total weight of the oil and the phospholipids, the oil comprises coffee oil, and the caffeine is released from the composition over a time period of at least 4 hours, the edible composition forming a lipid continuous phase which is liquid at 25° C., and the edible composition also forming self-assembled structures selected from the group consisting of a reversed hexagonal structure, a reversed micellar cubic structure, and combinations thereof.
7. The method according to claim 3 , wherein the composition is administered in a daily dose to provide between 0.5 mg and 10 mg of the caffeine per 1 kg body weight of the subject.
8. The method of claim 3 , wherein the composition is in an edible capsule.
9. The edible composition according to claim 1 , wherein the composition is in an edible capsule.
10. The method according to claim 6 , wherein the composition is administered in a daily dose to provide between 0.5 mg and 10 mg of the caffeine per 1 kg body weight of the subject.
11. The method of claim 6 , wherein the composition is in an edible capsule.
12. The edible composition according to claim 1 , wherein the phospholipids comprise phosphatidylcholine, and the oil further comprises limonene.
13. The edible composition according to claim 1 , wherein the phospholipids are from 36 wt. % to 55 wt. % of the total weight of the oil and the phospholipids.
14. The edible composition according to claim 1 , wherein the water is 28 wt. % to 35 wt. % of the edible composition.
15. The edible composition according to claim 1 , wherein the oil further comprises limonene and a weight ratio of the phospholipids: the limonene: the coffee oil is from about 1:4:5 to about 3:15:2.
16. The method of claim 3 , wherein the oil further comprises limonene and a weight ratio of the phospholipids: the limonene: the coffee oil is from about 1:4:5 to about 3:15:2.
17. The method of claim 6 , wherein the oil further comprises limonene and a weight ratio of the phospholipids: the limonene: the coffee oil is from about 1:4:5 to about 3:15:2.