Drug delivery devices having separable microneedles
The devices 400, 500 include microneedles 450, 550 that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release.
1. A drug delivery device comprising:
a substrate having a microneedle side and an opposing back side;
an array of microneedles extending from the microneedle side of the substrate, wherein the microneedles comprise a drug;
a supporting layer arranged on the opposing back side of the substrate; and
a predefined fracture region, provided about a proximal end of the microneedles and/or at the substrate located about each of the microneedles, configured to separate the array of microneedles from the substrate following application of a force to the substrate sufficient to at least partially penetrate a tissue surface with the array of microneedles,
wherein the predefined fracture region is configured to separate at least a distal part of the microneedles from the substrate upon application of a shearing force,
wherein the device further comprise a housing having a depressible portion, which is configured such that, upon depression of the depressible portion, the depressible portion applies or activates the shearing force; and
wherein the predefined fracture region (i) comprises an interface of different materials, and/or (ii) is located within a proximal portion of each microneedle such that following the separation a proximal part of the microneedle remains connected to the substrate.
2. The drug delivery device of claim 1 , wherein the force applied to the substrate sufficient to at least partially penetrate the tissue surface is a substantially perpendicular force relative to the substrate.
3. The drug delivery device of claim 1 , wherein the predefined fracture region located within the proximal portion of each microneedle comprises a brittle portion, a scored portion, a notched portion, one or more materials with anisotropic mechanical properties, or a combination thereof.
4. The drug delivery device of claim 1 , wherein the microneedles comprise a matrix material comprising a biodegradable polymer.
5. The drug delivery device of claim 4 , wherein the biodegradable polymer comprises polylactic acid (PLA), polyglycolic acid (PGA), or polylactive co-glycolic acid (PLGA).
6. The drug delivery device of claim 1 , wherein the microneedles comprise a water soluble matrix material.
7. The drug delivery device of claim 1 , wherein the microneedles comprise a matrix material which comprises a sugar.
8. The drug delivery device of claim 1 , wherein the microneedles comprise a matrix material comprising one or more of polyvinyl alcohol, dextran, carboxymethylcellulose, maltodextrin, sucrose, and trehalose.
9. The drug delivery device of claim 1 , wherein the substrate comprises a matrix material forming bulk of the substrate and the matrix material comprises a biocompatible polymeric material.
10. The drug delivery device of claim 9 , wherein the matrix material comprises an elastomer.
11. The drug delivery device of claim 10 , wherein the elastomer comprises polyurethane.
12. The drug delivery device of claim 1 , wherein the predefined fracture region comprises an interface of different materials and the interface comprises a well-defined angle between two differently sloping walls.
13. The drug delivery device of claim 1 , wherein the predefined fracture region comprises an interface of different materials and the interface is formed between a first casting forming the microneedles and a second casting forming a tapered substrate/base layer.
14. The drug delivery device of claim 13 , wherein the first casting comprises a sugar and the second casting comprise an elastomeric material.
15. The drug delivery device of claim 1 , wherein the microneedles do not each have a barb-like feature to resist withdrawal of the microneedle from the tissue surface following penetration thereof.
16. A drug delivery device comprising:
a substrate having a microneedle side and an opposing back side;
an array of microneedles extending from the microneedle side of the substrate, wherein the microneedles comprise a drug;
a supporting layer arranged on the opposing back side of the substrate; and
a predefined fracture region, provided about a proximal end of the microneedles and/or at the substrate located about each of the microneedles, configured to separate the array of microneedles from the substrate following application of a force to the substrate sufficient to at least partially penetrate a tissue surface with the array of microneedles,
wherein the predefined fracture region is configured to separate at least a distal part of the microneedles from the substrate upon application of a shearing force, and
wherein the predefined fracture region comprises an interface of different materials such that following the separation a proximal part of the microneedle remains connected to the substrate, and the interface comprises a well-defined angle between two differently sloping walls.
17. The drug delivery device of claim 16 , wherein the microneedles comprise a water soluble matrix material.
18. The drug delivery device of claim 16 , wherein the microneedles comprise a matrix material comprising a biodegradable polymer.
19. The drug delivery device of claim 18 , wherein the biodegradable polymer comprises polylactic acid (PLA), polyglycolic acid (PGA), or polylactive co-glycolic acid (PLGA).
20. The drug delivery device of claim 16 , wherein the microneedles comprise a matrix material which comprises a sugar.
21. The drug delivery device of claim 16 , wherein the microneedles comprise a matrix material comprising one or more of polyvinyl alcohol, dextran, carboxymethylcellulose, maltodextrin, sucrose, and trehalose.
22. The drug delivery device of claim 16 , wherein the substrate comprises a matrix material forming a bulk of the substrate and the matrix material comprises a biocompatible polymeric material.
23. The drug delivery device of claim 22 , wherein the matrix material comprises an elastomer.
24. The drug delivery device of claim 23 , wherein the elastomer comprises polyurethane.
25. A drug delivery device comprising:
a substrate having a microneedle side and an opposing back side;
an array of microneedles extending from the microneedle side of the substrate, wherein the microneedles comprise a drug;
a supporting layer arranged on the opposing back side of the substrate; and
a predefined fracture region, provided about a proximal end of the microneedles and/or at the substrate located about each of the microneedles, configured to separate the array of microneedles from the substrate following application of a force to the substrate sufficient to at least partially penetrate a tissue surface with the array of microneedles,
wherein the predefined fracture region is configured to separate at least a distal part of the microneedles from the substrate upon application of a shearing force, and
wherein the predefined fracture region comprises an interface of different materials such that following the separation a proximal part of the microneedle remains connected to the substrate and the interface is formed between a first casting forming the microneedles and a second casting forming a tapered substrate/base layer.
26. The drug delivery device of claim 25 , wherein the first casting comprises a sugar and the second casting comprise an elastomeric material.
27. The drug delivery device of claim 25 , wherein the microneedles comprise a water soluble matrix material.
28. The drug delivery device of claim 25 , wherein the microneedles comprise a matrix material comprising a biodegradable polymer.
29. The drug delivery device of claim 28 , wherein the biodegradable polymer comprises polylactic acid (PLA), polyglycolic acid (PGA), or polylactive co-glycolic acid (PLGA).
30. The drug delivery device of claim 25 , wherein the microneedles comprise a matrix material which comprises a sugar.
31. The drug delivery device of claim 25 , wherein the microneedles comprise a matrix material comprising one or more of polyvinyl alcohol, dextran, carboxymethylcellulose, maltodextrin, sucrose, and trehalose.
32. The drug delivery device of claim 25 , wherein the substrate comprises a matrix material forming bulk of the substrate and the matrix material comprises a biocompatible polymeric material.
33. The drug delivery device of claim 32 , wherein the matrix material comprises an elastomer.
34. The drug delivery device of claim 33 , wherein the elastomer comprises a polyurethane.