Capsid
There is described an AAV capsid protein having an amino acid sequence which has at least 98% identity to the sequence of SEQ ID NO: 3 or at least 94% identity to the sequence of SEQ ID NO: 4. Also described is a pharmaceutical composition, an AAV capsid and a viral particle comprising the capsid protein, a recombinant AAV vector comprising a nucleotide sequence which encodes for the capsid protein, and a host cell and a transgenic animal comprising the capsid protein or the vector. In addition, there is described a method of transferring a nucleic acid of interest into a mammal comprising introducing a recombinant AAV vector into the mammal, wherein the recombinant AAV vector comprises a gene of interest which is encapsidated into a capsid comprising the capsid protein.
1. An AAV capsid protein comprising an amino acid sequence
i) having the sequence of SEQ ID NO: 3; or
ii) having at least 99% identity to SEQ ID NO: 3 and is a hybrid capsid comprising regions of the AAV3B and AAV8 capsids.
2. The AAV capsid protein of claim 1 , wherein the amino acid sequence has at least 99.5% identity to SEQ ID NO: 3.
3. The AAV capsid protein of claim 1 , wherein the amino acid sequence has the sequence of SEQ ID NO: 3.
4. A polynucleotide encoding the capsid protein of claim 1 .
5. A viral particle comprising the capsid protein of claim 1 .
6. A pharmaceutical composition comprising the capsid protein of claim 1 , and one or more pharmaceutically acceptable excipients.