IP Library › Granted Patent US 12,467,065
Granted Patent B2
US 12,467,065 · App. 18/062,333 · Granted Nov 11, 2025

Recombinant adeno-associated virus capsids with enhanced human pancreatic tropism

Inventors: Katja Pekrun (Palo Alto, CA); Mark A. Kay (Los Altos, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University
C12N15/86A61K47/6901C07K14/015C07K14/075C12N15/102C12N7/00C12N15/902C12N2710/10041C12N2710/10071C12N2710/10134C12N2710/10141C12N2750/14123
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Quick Facts
Patent No.
US 12,467,065
App. No.
18/062,333
Granted
Nov 11, 2025
Kind
B2
Abstract

The present invention relates to variant AAV capsid polypeptides, wherein the variant AAV capsid polypeptides exhibit increased transduction and/or tropism in human pancreatic tissue or human islets as compared non-variant parent capsid polypeptides.

Claims (5)

1 . A method of using an AAV capsid polypeptide to deliver a nucleic acid to a subject, the method comprising the step of administering to the subject an AAV vector whose genome comprises the nucleic acid,

wherein the AAV capsid polypeptide is part of a functional AAV capsid,

wherein the functional AAV capsid packages a nucleic acid sequence, and

wherein the AAV capsid polypeptide sequence has the amino acid sequence selected from the group consisting of AAV-10A1 (SEQ ID NO: 1), AAV-10A3 (SEQ ID NO:2), AAV-10A4 (SEQ ID NO:3), AAV-10A5 (SEQ ID NO:4), AAV-18A1 (SEQ ID NO:5), AAV-10B1 (SEQ ID NO:6), AAV-10B3 (SEQ ID NO:7), AAV-10B5 (SEQ ID NO:8), AAV-10B6 (SEQ ID NO:9), AAV-10B7 (SEQ ID NO:10), AAV-18B2 (SEQ ID NO:12), and AAV-18B3 (SEQ ID NO:13).

2 . The method of claim 1 , wherein the nucleic acid sequence is selected from the group consisting of a non-coding RNA, a protein coding sequence, an expression cassette, and a sequence for homologous recombination.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 14, 2022
From: PEKRUN, KATJA; KAY, MARK A.
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 062093/0723 →
Continuity (4)
Division 16370735 · Mar 29, 2019
Provisional Application 62651010 · Mar 30, 2018
Provisional Application 62745226 · Oct 12, 2018
Related Publication 20230304039A1 · Sep 28, 2023
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