IP Library › Granted Patent US 10,413,548
Granted Patent B2
US 10,413,548 · App. 15/645,683 · Granted Sep 17, 2019

Methods and compositions for the inhibition of Pin1

Inventors: Kun Ping Lu (Newton, MA); Matthew Brian Boxer (Rockville, MD); Mindy Irene Emily Davis (Rockville, MD); Rajan Pragani (Rockville, MD); Min Shen (Rockville, MD); Anton Momtchilov Simeonov (Rockville, MD); Shuo Wei (Chestnut Hill, MA); Xiao Zhen Zhou (Newton, MA)
Assignees: Beth Israel Deaconess Medical Center, Inc.; The United States of America, as represented by the Secretary, Department of Health and Human Services
A61K31/5377A61K31/185A61K31/341A61K31/357A61K31/365A61K31/381A61K31/382A61K31/402A61K31/404A61K31/405A61K31/4025A61K31/427A61K31/428A61K31/4245A61K31/473A61K31/4704A61K31/496A61K45/06
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Quick Facts
Patent No.
US 10,413,548
App. No.
15/645,683
Granted
Sep 17, 2019
Kind
B2
Abstract

The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

Claims (4)

1. A method of inhibiting Pin1 by contacting Pin1 with a compound having a structure selected from Compound 9 and Compound 10:

or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 , wherein said Pin1 is in a cell.

3. The method of claim 2 , wherein said cell is a human cell.

Assignments (3)
CONFIRMATORY LICENSE Recorded Sep 13, 2021
From: BETH ISRAEL DEACONESS MEDICAL CENTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 057493/0964 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 23, 2018
From: LU, KUN PING; WEI, SHUO; ZHOU, XIAO ZHEN
To: BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
Reel/Frame 044696/0611 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 23, 2018
From: BOXER, MATTHEW BRIAN; DAVIS, MINDY IRENE EMILY; PRAGANI, RAJAN; SHEN, MIN; SIMEONOV, ANTON MOMTCHILOV
To: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Reel/Frame 044696/0838 →
Continuity (3)
Continuation 14406401
Provisional Application 61656806 · Jun 7, 2012
Related Publication 20170304310A1 · Oct 26, 2017
Cited By (1)
US 12,728,132