Granted Patent B2

US 10,314,818 · App. 15/655,739 · Granted Jun 11, 2019

Inventors: William Fenical (Del Mar, CA); Paul Jensen (San Diego, CA); Tracy Mincer (San Diego, CA); Robert H. R. Feling (Wiesbaden, DE)

Assignee: The Regents of the University of California

A61K31/407A61K31/397A61K31/424A61K31/43A61K45/06C07D491/04C07D491/044C12P17/18C12P17/188

Abstract

Claims (14)

1. A method of treating a central nervous system cancer in a human subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of the structure:

wherein:

R 1 to R 3 are each independently —H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, substituted cycloalkyl, alkoxy, substituted alkoxy, thioalkyl, substituted thioalkyl, hydroxy, halogen, amino, amido, carboxyl, —C(O)H, acyl, oxyacyl, carbamate, sulfonyl, sulfonamide or sulfuryl;

each R 4 is independently alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl;

E 1 to E 4 are each independently —O, —NR 5 , or —S, wherein R 5 is —H or C 1 -C 6 alkyl; and

x is 0 to 8.

2. The method of claim 1 , wherein

R 1 is a substituted alkyl; R 2 is methyl; R 3 is hydroxyl;

each R 4 is independently alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl;

E 1 , E 3 and E 4 are —O,

E 2 is —NR 5 , wherein R 5 is —H or C 1 -C 6 alkyl; and

x is 0 to 8.

3. The method of claim 1 , wherein the compound has the structure:

4. The method of claim 1 , wherein the compound has the structure:

Assignments (1)

Continuity (10)