Generation and analysis of chemical compound libraries
Various samples are generated on a substrate. The samples each includes or consists of one or more analytes. In some instances, the samples are generated through the use of gels or through vapor deposition techniques. The samples are used in an instrument for screening large numbers of analytes by locating the samples between a working electrode and a counter electrode assembly. The instrument also includes one or more light sources for illuminating each of the samples. The instrument is configured to measure the photocurrent formed through a sample as a result of the illumination of the sample.
1. An instrument, comprising:
samples located between a working electrode and a counter electrode assembly comprising a plurality of counter electrodes, the samples each including one or more analytes, wherein the distance between the working electrode and counter electrode assembly is less than 10 mm, and wherein the samples are immobilized directly on the working electrode assembly forming an electrical circuit;
one or more light sources that each act as a source of one or more light beams that are each incident on one or more of the samples;
an electrolyte between the working electrode and the counter electrode assembly and in contact with the samples; and
the electrolyte including a redox couple, the redox couple having an exchange current density of at least 1 mA cm −2 for platinum, gold and/or copper.
2. The instrument of claim 1 , wherein the redox couple has an exchange current density of at least 1 mA cm −2 for at least one of the counter electrodes.
3. The instrument of claim 1 , wherein the working electrode is transparent.
4. The instrument of claim 1 , wherein the distance between the working electrode and counter electrode assembly is less than 1 mm.
5. The instrument of claim 4 , wherein the samples are separated from eachother by more than 10 mm.
6. The instrument of claim 1 , wherein the redox couple is selected so that electrochemical oxidation and reduction can proceed without addition of a catalyst on the samples.
7. The instrument of claim 1 , wherein the electrolyte is in physical contact with the counter electrode assembly and the working electrode assembly.
8. The instrument of claim 6 , wherein the working electrode assembly can transfer electrons to the electrolyte.
9. The instrument of claim 1 , wherein the one or more analytes comprises a semiconductor light absorber.
10. The instrument of claim 9 , wherein the semiconductor light absorber absorbs light at wavelengths greater than 400 nm.
11. The instrument of claim 1 , wherein a plurality of samples are associated with each counter electrode of the plurality of counter electrodes.