Compositions and methods for modulating gastrointestinal microflora in a canine
The present invention relates to methods and compositions for modulating gastrointestinal microflora of a canine. In one embodiment, a method of modulating gastrointestinal microflora in a canine can comprise administering to the canine a pet food composition comprising from about 25% to about 60% protein, from about 5% to about 30% carbohydrates, fat, and fiber; where after administration, the Bacteroidetes to Firmicutes (B/F) ratio of the canine is less than 0.8.
1. A method of modulating gastrointestinal microflora in a canine, comprising:
administering to the canine a single pet food composition comprising from about 25% to about 60% protein, from about 5% to about 30% carbohydrates, fat, and fiber;
wherein, after administration, the Bacteroidetes to Firmicutes (B/F) ratio of the canine is less than 0.8.
2. The method of claim 1 , wherein the pet food composition comprises a first probiotic that decreases Bacteroidetes microflora in the canine.
3. The method of claim 2 , wherein the pet food composition comprises a second probiotic that increases Firmicutes microflora.
4. The method of claim 1 , wherein the pet food composition comprises a probiotic that increases Firmicutes microflora in the canine.
5. The method of claim 4 , wherein the probiotic is administered separately from the pet food composition.
6. The method of claim 4 , wherein the probiotic is added to the pet food composition prior to administering.
7. The method of claim 1 , further comprising identifying the canine as having diabetes, obesity, an inflammatory disease, a cardiovascular disease, a metabolic disorder, a musculoskeletal disorder, or cancer.
8. The method of claim 1 , wherein modulating gastrointestinal microflora of the canine is part of a treatment for diabetes, obesity, an inflammatory disease, a cardiovascular disease, a metabolic disorder, a musculoskeletal disorder, or cancer.
9. The method of claim 1 , wherein the Bacteroidetes to Firmicutes ratio (B/F) ratio of the canine is less than 0.7.
10. The method of claim 1 , wherein the pet food composition comprises from about 45% to about 60% protein.
11. The method of claim 1 , wherein the pet food composition comprises from about 10% to about 20% carbohydrates.
12. The method of claim 1 , wherein the pet food composition comprises a prebiotic.
13. The method of claim 1 , wherein the administration is on a regular basis.
14. The method of claim 1 , wherein B/F ratio is calculated from the presence of Streptococcus infantarius, Ruminococcus ruminococcus sp., [ Clostridium ] hiranonis, Clostridium perfringens, Enterococcus faecium, [ Clostridium ] bartlettii , [ Clostridium ] difficile , [ Ruminococcus ] gnavus, Lachnospiraceae bacterium, Blautia hansenii , [ Ruminococcus ] obeum, Faecalibacterium prausnitzii, Clostridium butyricum, Lactobacillus ruminis, Turicibacter sanguinis , and Lactobacillus acidophilus from the Firmicutes phylum and Bacteroides coprocola, Parabacteroides merdae, Bacteroides coprophilus, Prevotella copri , and Bacteroides bacteroides sp. from the Bacteroidetes phylum.
15. The method of claim 1 , wherein, after administration, Lactobacillus ruminis is decreased by 25%.