Gas conditioning
A method for reducing or preventing mesothelial cell damage by mixing a carrier gas and between 1 volume percent and 29 volume percent of nitrous oxide gas (N 2 O) to form a medicament and applying the medicament during surgery. The method can be used for prevention of adhesion formation, pain reduction, reducing or preventing acute inflammation, reducing or preventing CO 2 resorbtion or reducing tumor cell implantation upon surgery.
1. A method for reducing or preventing mesothelial cell damage during surgery comprising the steps of:
mixing a carrier gas and nitrous oxide gas in a mixer to form a medicament, wherein the nitrous oxide gas is between 5 and 20 volume percent, and
applying the medicament during surgery by flowing the medicament in or over a cavity over the mesothelial cells during surgery in a cavity to reduce or prevent mesothelial cell damage.
2. A method for reducing or preventing mesothelial cell damage during surgery comprising the steps of:
mixing a carrier gas and nitrous oxide gas in a mixer to form a medicament, wherein the nitrous oxide gas is between 5 and 10 volume percent, and
applying the medicament during surgery by flowing the medicament in or over a cavity over the mesothelial cells during surgery in a cavity to reduce or prevent mesothelial cell damage.
3. The method of claim 1 , wherein the carrier gas is carbon dioxide gas.
4. The method of claim 1 , wherein the solubility of the carrier gas is larger than 0.5 g/l in water.
5. The method of claim 1 , wherein applying the medicament comprises flowing the medicament during pneumoperitoneum.
6. The method of claim 1 , wherein applying the medicament comprises flowing the medicament during open surgery.
7. The method according to claim 1 , wherein applying the medicament during surgery furthermore comprises applying the medicament for reducing or preventing pain.
8. The method according to claim 1 , wherein applying the medicament during surgery furthermore comprises applying the medicament for reducing or preventing acute inflammation.
9. The method according to claim 1 , wherein applying the medicament during surgery furthermore comprises applying the medicament for reducing or preventing CO2 resorbtion.
10. The method according to claim 1 , wherein applying the medicament during surgery furthermore comprises applying the medicament for reducing tumor implantation reduction.
11. The method according to claim 1 , wherein applying the medicament during surgery furthermore comprises applying the medicament for reducing or preventing adhesion formation.
12. The method according to claim 1 , further comprising the step of removing environmental air or unwanted gasses present in the cavity.
13. The method according to claim 1 , wherein applying the medicament during surgery includes deliberately insufflating the cavity during the surgery.
14. The method according to claim 6 , wherein during open surgery, when the cavity is opened and exposed to environmental air, the medicament flows over the cavity removing the environmental air.
15. The method according to claim 2 , wherein the medicament further comprises a concentration of oxygen in the range of 1 to 10%.
16. The method according to claim 15 , wherein the concentration of oxygen is in the range of 3-4%.
17. The method according to claim 16 , further comprising the step of maintaining a temperature of the medicament between 31-32° C. and cooling the cavity to 30-32° C.
18. The method according to claim 2 , wherein the surgery is a laparoscopy.
19. The method according to claim 6 , wherein the open surgery comprises providing an incision through a wall of the cavity.