Vaccine compositions comprising C—C motif chemokine 22 (CCL22) or fragments thereof
The present disclosure relates to CCL22 as a novel T cell target in cancer immunosuppression.
1. An immunogenically active peptide fragment of CCL22 consisting of at the most 50 consecutive residues of SEQ ID NO: 12, wherein said peptide fragment is of at least 25 amino acids and contains a sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, and SEQ ID NO: 11.
2. The peptide fragment according to claim 1 , wherein the peptide fragment comprises the sequence of SEQ ID NO: 5.
3. A composition comprising the peptide fragment of claim 1 and an adjuvant.
4. The composition according to claim 3 , further comprising an immunogenically active protein or peptide fragment selected from a protein or peptide fragment, which is not CCL22.
5. The composition according to claim 3 , wherein the adjuvant is selected from the group consisting of bacterial DNA based adjuvants, oil/surfactant based adjuvants, viral dsRNA based adjuvants and imidazochinilines.