Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection
Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.
1. A compound or a hydrate, isomer, or pharmaceutically acceptable salt thereof having the structure:
wherein
R 1 is C 2 -C 6 alkyl;
R 2 is hydrogen, alkenyl, or oxo;
X is —CHCH—, —NH—, —C═N—, or —N═C—;
when X is —CHCH—, R 2 is hydrogen, alkenyl, or oxo; when X is —NH—, —C═N—, or —N═C—, R 2 is hydrogen, or oxo;
n is 1-6.
2. The compound of claim 1 , wherein X is —NH—, —C═N—, —N═C—.
3. The compound of claim 1 , wherein X is —CHCH—.
4. The compound of claim 1 , wherein n is 3, 4, or 5.
5. The compound of claim 1 , wherein n is 1, 2, 3, 4, or 5.
6. The compound of claim 1 having the structure:
7. The compound of claim 1 having the structure:
8. A pharmaceutical composition comprising the compound of claim 1 in admixture with a pharmaceutically acceptable carrier.
9. A compound selected from the group consisting of:
and hydrates, isomers, or pharmaceutically acceptable salts thereof.
10. A pharmaceutical composition comprising the compound of claim 9 in admixture with a carrier.
11. The compound of claim 1 having the structure:
12. The compound of claim 1 having the structure:
wherein n is 1.