IP Library Granted Patent US 10,010,302
Granted Patent B2
US 10,010,302 · App. 15/802,225 · Granted Jul 3, 2018

System and method for generating a 2D image from a tomosynthesis data set

Inventors: Christopher Ruth (Boxford, MA); Andrew P. Smith (Lexington, MA); Jay Stein (Boston, MA)
Assignee: HOLOGIC, INC.
A61B6/502A61B6/025A61B6/461G06T11/003G06T11/006G06T11/008G06T11/60G06T19/20G06T2207/10081G06T2207/10112G06T2207/20221G06T2207/30068G06T2207/30204G06T2210/41G06T2219/2008
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Quick Facts
Patent No.
US 10,010,302
App. No.
15/802,225
Granted
Jul 3, 2018
Kind
B2
Abstract

A 2D mammogram image is synthesized from at least one of tomosynthesis projection images and/or the tomosynthesis reconstructed image data. In a simplest form, the mammogram may be synthesized by selecting one of the tomosynthesis projection images for display as a synthesized mammogram. Other methods of synthesizing a mammogram include re-projecting and filtering projection data and/or reconstructed data. The synthesized mammogram is advantageously displayed together with at least a portion of the reconstructed data to aid in review of the reconstructed data. The present invention thus provides a familiar image which may be used to facilitate review of a tomosynthesis data set.

Claims (34)

1. A system for evaluating breast tissue, comprising:

a processor configured to

process a plurality of tomosynthesis projection images of a patient's breast tissue to generate a plurality of tomosynthesis reconstructed images;

generate a tomosynthesis data set comprising one or more of the plurality of tomosynthesis projection images and/or one or more of the plurality of tomosynthesis reconstructed images;

analyze the tomosynthesis data set using computer aided detection (CAD); and

generate a two-dimensional synthesized mammogram from the tomosynthesis data set, wherein the synthesized mammogram comprises a synthesized two-dimensional image that simulates a conventional mammography image.

2. The system of claim 1 , wherein the two-dimensional synthesized mammogram is generated only from the plurality of tomosynthesis reconstructed images.

3. The system of claim 1 , wherein the two-dimensional synthesized mammogram is generated only from the plurality of tomosynthesis projection images.

4. The system of claim 1 , wherein the processor is configured to generate a CAD mark to be displayed on the synthesized mammogram by analyzing the tomosynthesis data.

5. The system of claim 1 , further comprising a display device operatively coupled with the processor, wherein processor is configured to cause the synthesized mammogram on the display device.

6. The system of claim 5 , wherein the processor is configured to generate a CAD mark by analyzing the tomosynthesis data set, and to cause the generated CAD mark to be displayed on the synthesized mammogram on the display device.

7. The system of claim 5 , wherein the processor is configured to generate a CAD mark by analyzing the tomosynthesis data set, and to cause the generated CAD mark to be displayed on a tomosynthesis reconstructed image from the plurality of tomosynthesis reconstructed images on the display device.

8. The system of claim 5 , wherein the processor is configured to generate a CAD mark by analyzing the tomosynthesis data set, and to cause the generated CAD mark to be displayed on a tomosynthesis projection image from the plurality of tomosynthesis projection images on the display device.

9. The system of claim 5 , wherein the processor is configured to cause one of a tomosynthesis reconstructed image from the plurality of tomosynthesis reconstructed images and a tomosynthesis projection image from the plurality of tomosynthesis projection images to be displayed along with the synthesized mammogram on the display device.

10. The system of claim 5 , wherein the display device is a radiologist workstation.

11. A system for generating and displaying a synthesized mammogram of a patient's breast tissue, the system comprising a specially configured computer system, the computer system comprising

a reconstruction engine configured to receive a tomosynthesis data set comprising one or more of a plurality of tomosynthesis projection images and/or a plurality of tomosynthesis reconstructed slices, and

a synthesizer configured to generate a two-dimensional synthesized mammogram solely from the tomosynthesis data set using computer aided detection (CAD), wherein the synthesized mammogram comprises a synthesized two-dimensional image that simulates a conventional mammography image.

12. The system of claim 11 , wherein the synthesizer is further configured to analyze the tomosynthesis data set using CAD to generate a CAD mark to be displayed on the synthesized mammogram.

13. A system for evaluating a patient's breast tissue, comprising:

an image acquisition system configured to acquire tomosynthesis projection images of a patient's breast; and

an image processing system operatively coupled with the image acquisition system, the image processing system configured to

generate an x-ray tomosynthesis data set of the patient's breast, the x-ray tomosynthesis data set comprising one or more acquired tomosynthesis projection images and one or more tomosynthesis reconstructed images generated therefrom, and

synthesize a two-dimensional mammogram solely from the x-ray tomosynthesis data set, wherein the synthesized mammogram comprises a synthesized two-dimensional image that simulates a conventional mammography image.

14. The system of claim 13 , wherein the image processing system is configured to perform filtering of at least one of the tomosynthesis projection images prior to synthesizing the two-dimensional mammogram.

15. The system of claim 13 , further comprising a display device operatively coupled with the image processing system and configured to display the synthesized mammogram on the display device.

16. The system of claim 15 , wherein the image processing system is further configured to process the x-ray tomosynthesis data set to obtain a CAD mark, and

cause the CAD mark to be displayed on the synthesized mammogram.

17. The system of claim 16 , wherein the displayed CAD mark is overlaid on the synthesized mammogram.

18. The system of claim 15 , wherein the image processing system is further configured to

reconstruct the tomosynthesis projection images into a three-dimensional reconstructed image comprising a plurality of image slices, and

cause the plurality of image slices to be sequentially or concurrently displayed with the synthesized mammogram on the display device.

19. The system of claim 18 , wherein the image processing system is configured to reconstruct the tomosynthesis projection images onto a three-dimensional first coordinate system to provide an initial reconstruction.

20. The system of claim 13 , wherein image processing system is configured to synthesize the two-dimensional mammogram by projecting at least one tomosynthesis slice image having a pixel spacing that differs from a pixel spacing of a mammogram onto a mammogram coordinate system.

Assignments (3)
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
SECURITY INTEREST Recorded Oct 19, 2018
From: HOLOGIC, INC.; GEN-PROBE INCORPORATED; CYNOSURE, INC.; FAXITRON BIOPTICS, LLC
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 047272/0347 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 2, 2017
From: RUTH, CHRISTOPHER; SMITH, ANDREW; STEIN, JAY
To: HOLOGIC, INC.
Reel/Frame 044023/0279 →
Continuity (6)
Continuation 15088844 · Apr 1, 2016
Continuation 14549604 · Nov 21, 2014
Continuation 14044959 · Oct 3, 2013
Continuation 12471981 · May 26, 2009
Continuation In Part 12276006 · Nov 21, 2008
Related Publication 20180055470A1 · Mar 1, 2018
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