Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
1. An apparatus for treating a neural condition of a patient, comprising:
a signal generator for generating electrical stimulation for application to neural tissue of the patient;
wireless communication circuitry for conducting wireless communications with an external programming device;
a header structure for connecting to one or more implantable stimulation leads for application of electrical pulses to neural tissue of the patient; and
a controller operatively coupled to the signal generator, the controller being configured to control the signal generator to direct an application of electrical stimulation to the patient in a manner such that the electrical stimulation has a burst frequency and an intra-burst frequency greater than the burst frequency, wherein the controller directs application of the electrical stimulation according to a duty cycle with stimulation-on periods where electrical stimulation is applied with intervening stimulation-off periods where electrical stimulation is temporarily halted between respective stimulation on-periods, and wherein the duty cycle stimulation-on periods and stimulation-off periods are controlled by a programmable duty cycle parameter set by communication with the external programming device;
wherein the apparatus is adapted for implantation in the patient.
2. The apparatus of claim 1 wherein the intra-burst frequency varies from burst to burst.
3. The apparatus of claim 1 wherein the burst frequency is generally similar to natural brainwaves.
4. The apparatus of claim 3 wherein the natural brainwaves are selected from a group consisting of alpha, beta, gamma, delta or theta frequency bands.
5. The apparatus of claim 1 wherein the intra-burst frequency is about 50 Hz to about 500 Hz.
6. The apparatus of claim 1 wherein the electrical stimulation is directed to different electrodes.