Clay-based hemostatic agents
A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.
1. A method for manufacturing a hemostatic device comprising:
providing an absorbent substrate;
applying a clay material that is distinct from the substrate to a surface of the substrate;
applying a binder comprising glycerol that is distinct from the substrate to the substrate to adhere at least a portion of the clay material to the surface of the substrate so that the surface is substantially free of loose clay;
wherein the clay material is positioned on the surface of the device in a region configured to contact blood from a bleeding wound, thereby promoting clotting;
wherein the hemostatic device is configured to absorb blood from the bleeding wound.
2. The method of claim 1 , wherein the clay material is selected from the group consisting of attapulgite, bentonite, kaolin, and combinations of the foregoing materials.
3. The method of claim 1 , wherein the clay comprises kaolin.
4. The method of claim 1 , wherein the clay material and the binder are applied as a single step.
5. The method of claim 1 , wherein the absorbent substrate is fabricated from a material selected from the group consisting of cotton, silk, wool, plastic, cellulose, rayon, polyester, and combinations of the foregoing.
6. The method of claim 1 , wherein the absorbent substrate is flexible to allow the absorbent substrate to form to a shape of the bleeding wound and to retain the shape of the bleeding wound.
7. The method of claim 1 , wherein the binder is applied to the absorbent substrate by a spraying process.
8. The method of claim 1 , wherein the binder and the clay material are applied to the absorbent substrate by a spraying process.
9. The method of claim 1 , wherein the binder is applied to the absorbent substrate by immersing the absorbent substrate in a liquid comprising the binder.
10. The method of claim 1 , wherein the binder and the clay material are applied to the absorbent substrate by a slot-die technique.
11. The method of claim 1 , wherein the binder and the clay material are applied to the absorbent substrate by rolling the binder and the clay material on the absorbent substrate.
12. A method for manufacturing a hemostatic device comprising:
providing an absorbent substrate;
applying a clay material that is distinct from the substrate to a surface of the substrate;
applying a binder comprising an alginate that is distinct from the substrate to a surface of the substrate to adhere at least a portion of the clay material to the surface of the substrate so that the surface is substantially free of loose clay;
wherein the clay material is positioned on the surface of the device in a region configured to contact blood from a bleeding wound, thereby promoting clotting;
wherein the hemostatic device is configured to absorb blood from the bleeding wound.
13. The method of claim 12 , wherein the clay material is selected from the group consisting of attapulgite, bentonite, kaolin, and combinations of the foregoing materials.
14. The method of claim 12 , wherein the clay comprises kaolin.
15. The method of claim 12 , wherein the clay material and the binder are applied as a single step.
16. The method of claim 12 , wherein the absorbent substrate is fabricated from a material selected from the group consisting of cotton, silk, wool, plastic, cellulose, rayon, polyester, and combinations of the foregoing.
17. The method of claim 12 , wherein the absorbent substrate is flexible to allow the absorbent substrate to form to a shape of the bleeding wound and to retain the shape of the bleeding wound.
18. The method of claim 12 , wherein the binder is applied to the absorbent substrate by a spraying process.
19. The method of claim 12 , wherein the binder and the clay material are applied to the absorbent substrate by a spraying process.
20. The method of claim 12 , wherein the binder is applied to the absorbent substrate by immersing the absorbent substrate in a liquid comprising the binder.
21. The method of claim 12 , wherein the binder and the clay material are applied to the absorbent substrate by a slot-die technique.
22. The method of claim 12 , wherein the binder and the clay material are applied to the absorbent substrate by rolling the binder and the clay material on the absorbent substrate.