Methods for implanting and reversing stimuli-responsive implants
Described are methods for reversible occlusion of a body lumen by way of degradation as a result of exposure to one or more stimuli such as light. The methods include administering one or more substance(s) into a body lumen of a subject and forming a stimuli-responsive polymer mass in the body lumen from the one or more substance(s). The mass is sufficient to occlude the body lumen in a manner that prevents transport of at least one material through the body lumen and is susceptible to on-command reversal in the body lumen upon exposure to one or more stimuli. The methods include administering one or more stimuli to a polymer mass in a body lumen for a time and intensity to cause the reverse the polymer mass. The methods are particular useful for applications in which it is desirable to temporarily occlude a body lumen, such as male and female contraception.
1. A method comprising:
administering one or more substance(s) into a body lumen of a subject; and
forming a stimuli-responsive polymer mass in the body lumen from the one or more substance(s);
wherein the mass is sufficient to occlude the body lumen in a manner that prevents transport of at least one material through the body lumen;
wherein the polymer mass is susceptible to reversal in the body lumen upon exposure to one or more exogenous stimuli such that after the reversal is performed, the polymer mass no longer occludes the body lumen;
wherein the mass has the occlusive effect of having pores sized to block the flow of cells within the body lumen and upon exposure to the one or more exogenous stimuli the occlusive effect is reversed to increase the pore size and restore the flow of the cells.
2. The method of claim 1 , wherein the one or more exogenous stimuli comprises light.
3. The method of claim 2 , wherein the light is monochromatic, ultraviolet, near infrared, infrared, or visible light.
4. The method of claim 2 , wherein the light is administered through tissue overlying the body lumen.
5. The method of claim 2 , wherein the light is administered by way of a catheter or needle placed in the body lumen.
6. The method of claim 1 , wherein the one or more substance(s) are injected through a needle or catheter or a combination of both.
7. The method of claim 6 , wherein the needle or catheter comprises multiple lumens.
8. The method of claim 7 , wherein the needle or catheter comprises two or more lumens, with a second lumen capable of delivering a second stimulus.
9. The method of claim 1 , wherein the one or more exogenous stimuli is one or more of ultrasound, x-ray, ultraviolet, visible, near infrared, infrared, thermal, magnetic, electric, heat, vibrations, mechanical disruption, aqueous solutions, organic solvent, aqueous-organic mixture, enzymatic, protein(s), peptide(s), small organic molecules, large organic molecules, nanoparticles, microparticles, quantum dots, carbon-based materials, and/or any combination thereof.
10. The method of claim 9 , wherein the one or more exogenous stimuli is one or more of ultrasound, ultraviolet, visible, near infrared, infrared, magnetic, vibrations, protein(s), peptide(s), small organic molecules, large organic molecules, nanoparticles, microparticles, quantum dots, carbon-based materials, and/or any combination thereof.
11. The method of claim 1 , wherein the one or more substance(s) is a polymeric precursor material.
12. The method of claim 11 , wherein the polymeric precursor material comprises natural or synthetic monomers, polymers or copolymers, biocompatible monomers, polymers or copolymers, polystyrene, neoprene, polyetherether 10 ketone (PEEK), carbon reinforced PEEK, polyphenylene, polyetherketoneketone (PEKK), polyaryletherketone (PAEK), polyphenylsulphone, polysulphone, polyurethane, polyethylene, low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), high-density polyethylene (HDPE), polypropylene, polyetherketoneetherketoneketone (PEKEKK), nylon, fluoropolymers, polytetrafluoroethylene (PTFE or TEFLON®), TEFLON® TFE (tetrafluoroethylene), polyethylene terephthalate (PET or PETE), TEFLON® FEP (fluorinated ethylene propylene), TEFLON® PFA (perfluoroalkoxy alkane), and/or polymethylpentene (PMP) styrene maleic anhydride, styrene maleic acid (SMA), polyurethane, silicone, polymethyl methacrylate, polyacrylonitrile, poly (carbonate-urethane), poly (vinylacetate), nitrocellulose, cellulose acetate, urethane, urethane/carbonate, polylactic acid, polyacrylamide (PAAM), poly (N-isopropylacrylamine) (PNIPAM), poly (vinylmethylether), poly (ethylene oxide), poly (ethyl (hydroxyethyl) cellulose), poly(2-ethyl oxazoline), polylactide (PLA), polyglycolide (PGA), poly(lactide-co-glycolide) PLGA, poly(e-caprolactone), polydiaoxanone, polyanhydride, trimethylene carbonate, poly(β-hydroxybutyrate), poly(g-ethyl glutamate), poly(DTH-iminocarbonate), poly(bisphenol A iminocarbonate), poly(orthoester) (POE), polycyanoacrylate (PCA), polyphosphazene, polyethyleneoxide (PEO), polyethylene glycol (PEG) or any of its derivatives, polyacrylacid (PAA), polyacrylonitrile (PAN), polyvinylacrylate (PVA), polyvinylpyrrolidone (PVP), polyglycolic lactic acid (PGLA), poly(2-hydroxypropyl methacrylamide) (pHPMAm), poly(vinyl alcohol) (PVOH), PEG diacrylate (PEGDA), poly(hydroxyethyl methacrylate) (pHEMA), N-isopropylacrylamide (NIPA), poly(vinyl alcohol) poly(acrylic acid) (PVOH-PAA), collagen, silk, fibrin, gelatin, hyaluron, cellulose, chitin, dextran, casein, albumin, ovalbumin, heparin sulfate, starch, agar, heparin, alginate, fibronectin, fibrin, keratin, pectin, elastin, ethylene vinyl acetate, ethylene vinyl alcohol (EVOH), polyethylene oxide, PLA or PLLA (poly(L-lactide) or poly(L-lactic acid)), poly(D,L-lactic acid), poly(D,L-lactide), polydimethylsiloxane or dimethicone (PDMS), poly(isopropyl acrylate) (PIPA), polyethylene vinyl acetate (PEVA), PEG styrene, polytetrafluoroethylene RFE, TEFLON® RFE, KRYTOX® RFE, fluorinated polyethylene (FLPE or NALGENE®), methyl palmitate, temperature responsive polymers, poly(N-isopropylacrylamide) (NIPA), polycarbonate, polyethersulfone, polycaprolactone, polymethyl methacrylate, polyisobutylene, nitrocellulose, medical grade silicone, cellulose acetate, cellulose acetate butyrate, polyacrylonitrile, poly(lactide-co-caprolactone (PLCL), and/or chitosan.
13. The method of claim 1 , wherein the body lumen comprises an artery, vein, capillary, lymphatic vessel, a vas deferens, epididymis, or a fallopian tube; a duct, a bile duct, a hepatic duct, a cystic duct, a pancreatic duct, or a parotid duct; an organ, a uterus, prostate, or any organ of the gastrointestinal tract or circulatory system or respiratory system or nervous system; a subcutaneous space; or an interstitial space.
14. The method of claim 1 , wherein the at least one material is a sperm cell and the body lumen is a vas deferens.
15. The method of claim 1 , wherein the at least one material is an oocyte and the body lumen is a fallopian tube.
16. The method of claim 1 , wherein the administering of one or more of the substance(s) is performed with a needle injected through a wall of the body lumen.
17. The method of claim 1 , wherein the stimuli-responsive polymer mass swells greater than 100%.