IP Library › Granted Patent US 12,383,421
Granted Patent B2
US 12,383,421 · App. 16/156,947 · Granted Aug 12, 2025

Contraceptive devices

Inventors: Kevin Eisenfrats (Charlottesville, VA); Gregory Grover (Charlottesville, VA)
Assignee: Contraline, Inc.
A61F6/206A61B8/0841A61B8/085A61B17/1204A61B17/12186A61B17/1219A61B18/245A61L24/001A61L24/043A61L24/046A61B8/481A61B8/486A61B8/488A61B2017/00831A61B2017/1205A61B17/3403A61B2018/00404A61B2018/00547A61B2018/00559A61B18/14A61F6/02A61F6/202A61F6/22A61K41/0028A61L2400/06A61L2430/36A61N2007/0004
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Quick Facts
Patent No.
US 12,383,421
App. No.
16/156,947
Granted
Aug 12, 2025
Kind
B2
Abstract

Described are methods for reversible occlusion of a body lumen by way of degradation as a result of exposure to one or more stimuli such as light. The methods include administering one or more substance(s) into a body lumen of a subject and forming a stimuli-responsive polymer mass in the body lumen from the one or more substance(s). The mass is sufficient to occlude the body lumen in a manner that prevents transport of at least one material through the body lumen and is susceptible to on-command reversal in the body lumen upon exposure to one or more stimuli. The methods include administering one or more stimuli to a polymer mass in a body lumen for a time and intensity to cause the reverse the polymer mass. The methods are particular useful for applications in which it is desirable to temporarily occlude a body lumen, such as male and female contraception.

Claims (19)

1. A composition for a hydrogel comprising:

a multi-arm polyethylene glycol terminated with a thiol and a multi-arm polyethylene glycol terminated with a maleimide, present in the composition at a weight percent of 10-50%;

wherein the composition does not comprise a component comprising a silk backbone and is in an injectable form and crosslinkable to create an occlusion within a body lumen, and has a mass percent swelling of 100-1000% upon implantation in the body lumen; and

wherein the occlusion has a lifetime in vivo of one year or greater.

2. The composition of claim 1 , wherein the multi-arm polyethylene glycol terminated with the thiol and the multi-arm polyethylene glycol terminated with the maleimide are crosslinked in situ.

3. The composition of claim 1 , wherein the multi-arm polyethylene glycol terminated with the thiol and/or the multi-arm polyethylene glycol terminated with the maleimide are dissolved in an aqueous solvent or combination of aqueous and organic solvent prior to forming the composition.

4. The composition of claim 1 , wherein the multi-arm polyethylene glycol terminated with the thiol and/or the multi-arm polyethylene glycol terminated with the maleimide are present in and have a weight percent ranging from about 1 to 30% in solvent.

5. The composition of claim 1 , wherein the multi-arm polyethylene glycol terminated with the thiol and/or the multi-arm polyethylene glycol terminated with the maleimide comprises a Y-shaped, 3-arm, 4-arm, 6-arm, or 8-arm structure.

6. The composition of claim 1 , wherein the multi-arm polyethylene glycol terminated with the thiol and/or the multi-arm polyethylene glycol terminated with the maleimide are present in and have a viscosity of less than or equal to 7 Pa*s in solvent.

7. The composition of claim 1 , wherein the multi-arm polyethylene glycol terminated with the thiol and/or the multi-arm polyethylene glycol terminated with the maleimide are dissolved in a solvent with a pH 4-11.

8. The composition of claim 1 , wherein the composition is capable of being delivered using one or more of a needle, catheter, angiocath, needle-sheathed catheter, catheter-sheathed needle, over-the-needle catheter, catheter system, needle system, syringe, instrument, hypodermic needle, single lumen catheter, multi-lumen catheter, single lumen needle, multi-lumen needle, consumable needle, consumable catheter, nozzle, plastic tips, dual-barrel injection system, single-use or disposable device, multi-use device, or combinations thereof.

9. The composition of claim 1 , wherein the body lumen comprises an artery, vein, capillary, vessel, tissue, intra-organ space, lymphatic vessel, vas deferens, epididymis, fallopian tube, duct, bile duct, hepatic duct, cystic duct, pancreatic duct, parotid duct, organ, uterus, prostate, organ of the gastrointestinal tract or circulatory system or respiratory system or nervous system, subcutaneous space, or interstitial space, or combinations thereof.

10. The composition of claim 1 , wherein the occlusion is capable of a life span of from 1 year to 5 years.

11. The composition of claim 1 , wherein crosslinking is capable of occurring within a delivery device, such that the hydrogel is delivered.

12. The composition of claim 1 , wherein the composition is imageable using ultrasound.

13. The composition of claim 1 , wherein the multi-arm polyethylene glycol terminated with a thiol and the multi-arm polyethylene glycol terminated with a maleimide are each present in the composition at a weight percent of 10-20%.

14. The composition of claim 1 , wherein the multi-arm polyethylene glycol terminated with a thiol and the multi-arm polyethylene glycol terminated with a maleimide are each present in the composition at a weight percent of 10%.

15. The composition of claim 1 , wherein the multi-arm polyethylene glycol terminated with a thiol and the multi-arm polyethylene glycol terminated with a maleimide are each present in the composition at a weight percent of 20%.

16. The composition of claim 1 , wherein the body lumen comprises a vas deferens.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 11, 2018
From: EISENFRATS, KEVIN; GROVER, GREG; MORAN, ERIC
To: CONTRALINE, INC.
Reel/Frame 047133/0626 →
Continuity (4)
Continuation In Part 15863759 · Jan 5, 2018
Provisional Application 62442583 · Jan 5, 2017
Provisional Application 62566592 · Oct 2, 2017
Related Publication 20190038454A1 · Feb 7, 2019
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