IP Library › Granted Patent US 10,336,778
Granted Patent B2
US 10,336,778 · App. 15/885,258 · Granted Jul 2, 2019

Prodrugs of glutamine analogs

Inventors: Barbara Slusher (Kingsville, MD); Rana Rais (West Friendship, MD); Lukas Tenora (Prague, CZ); Pavel Majer (Sykesville, MD); Andrej Jancarik (Koprivnice, CZ)
Assignees: The Johns Hopkins University; Ústav organické chemie a biochemie AV {hacek over (C)}R, v.v.i.
C07F9/2458A61K31/404A61P35/00C07C227/14C07C245/18C07C271/22C07D209/18C07D209/20C07D211/90C07D263/04C07D263/18C07D309/10C07D317/38C07D317/40C07D473/34C07F9/65616C07H15/203C07H19/207C07K5/06026C07K5/06156C07K5/0808A61K38/00
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Quick Facts
Patent No.
US 10,336,778
App. No.
15/885,258
Granted
Jul 2, 2019
Kind
B2
Abstract

The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 2 ′, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.

Claims (4)

1. A compound selected from the group consisting of:

2. The compound of claim 1 which is:

3. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier, diluent, or excipient.

4. A pharmaceutical composition comprising the compound of claim 2 and a pharmaceutically acceptable carrier, diluent, or excipient.

Assignments (3)
SECURITY INTEREST Recorded Jul 12, 2023
From: DRACEN PHARMACEUTICALS, INC.
To: DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C), AS COLLATERAL AGENT
Reel/Frame 064232/0765 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 17, 2018
From: SLUSHER, BARBARA; RAIS, RANA
To: THE JOHNS HOPKINS UNIVERSITY
Reel/Frame 045562/0158 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 16, 2018
From: TENORA, LUKAS; MAJER, PAVEL; JANCARIK, ANDREJ
To: ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AV CR, V.V.I.
Reel/Frame 045255/0676 →
Continuity (3)
Continuation In Part PCTUS2016044767 · Jul 29, 2016
Provisional Application 62199566 · Jul 31, 2015
Related Publication 20180222930A1 · Aug 9, 2018
Cited By (4)
US 12,195,419 US 12,240,797 US 12,616,679 US 12,637,415