Compositions comprising citrulline and leucine and their use in the treatment of diabetes and metabolic syndrome
Compositions contain citrulline and leucine or a metabolite thereof including, for example, a synergistic amount of citrulline and leucine. Such compositions may be used in methods for the treatment of pre-diabetes, metabolic syndrome, hyperglycemia, or diabetes.
1. A method of treating hyperglycemia in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of citrulline and a therapeutically effective amount of leucine,
wherein the subject is administered a weight-based dose of the citrulline and the leucine.
2. The method of claim 1 , wherein the therapeutically effective amount of citrulline and the therapeutically effective amount of leucine result in a synergistic effect.
3. The method of claim 1 , wherein the citrulline and the leucine are administered to the subject using a regimen selected from the group consisting of weekly, daily, two times a day, and three times a day.
4. The method of claim 1 , wherein the subject is administered a fixed amount of the citrulline and the leucine.
5. The method of claim 1 , wherein the weight-based dose is about 0.01 g/kg to about 0.3 g/kg of the citrulline and 0.01 g/kg to about 0.3 g/kg of the leucine.
6. The method of claim 1 , wherein the weight-based dose is 1.0 g/kg of the citrulline and 1.0 g/kg of the leucine.
7. The method of claim 1 , wherein a pharmaceutical composition is administered to the subject that comprises both the therapeutically effective amount of the citrulline and the therapeutically effective amount of the leucine.
8. The method of claim 1 , wherein the therapeutically effective amount of the citrulline and the therapeutically effective amount of the leucine are administered orally.
9. The method of claim 1 , wherein the subject is administered protein in conjunction with the citrulline and the leucine.