IP Library › Granted Patent US 10,179,765
Granted Patent B2
US 10,179,765 · App. 15/961,441 · Granted Jan 15, 2019

N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

Inventors: John P. Toscano (Glen Arm, MD); Frederick Arthur Brookfield (Abingdon, GB); Andrew D. Cohen (Mamaroneck, NY); Stephen Martin Courtney (Abingdon, GB); Lisa Marie Frost (Abingdon, GB); Vincent Jacob Kalish (Annapolis, MD)
Assignees: Cardioxyl Pharmaceuticals, Inc.; The Johns Hopkins University
C07C311/48C07C317/14C07C323/67C07D213/74C07D231/18C07D261/10C07D263/58C07D285/125C07D295/096C07D307/82C07D309/12C07D317/14C07D333/34C07D333/62
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Quick Facts
Patent No.
US 10,179,765
App. No.
15/961,441
Granted
Jan 15, 2019
Kind
B2
Abstract

The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

Claims (2)

1. A compound which is

2. A compound which is

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 9, 2022
From: CARDIOXYL PHARMACEUTICALS INC.
To: THE JOHNS HOPKINS UNIVERSITY
Reel/Frame 062041/0565 →
Continuity (8)
Continuation 15640342 · Jun 30, 2017
Continuation 15286145 · Oct 5, 2016
Continuation 14857308 · Sep 17, 2015
Continuation 14280133 · May 16, 2014
Continuation 13213480 · Aug 19, 2011
Continuation 11724792 · Mar 16, 2007
Provisional Application 60783556 · Mar 17, 2006
Related Publication 20180244610A1 · Aug 30, 2018
Cited By (1)
US 12,186,301