IP Library › Granted Patent US 10,092,628
Granted Patent B2
US 10,092,628 · App. 15/966,288 · Granted Oct 9, 2018

Treating cardiovascular or renal diseases

Inventors: Yasuhiro Ikeda (Rochester, MN); Stephen James Russell (Rochester, MN); Alessandro Cataliotti (Rochester, MN); John C. Burnett, Jr. (Rochester, MN); Jason M. Tonne (Rochester, MN)
Assignee: Mayo Foundation for Medical Education and Research
A61K38/2242C12N7/00C12N2750/14143C12N2750/14171
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Quick Facts
Patent No.
US 10,092,628
App. No.
15/966,288
Granted
Oct 9, 2018
Kind
B2
Abstract

This document provides methods and materials for treating cardiovascular and/or renal diseases. For example, AAV9 vectors designed to express natriuretic polypeptides, nucleic acid molecules encoding natriuretic polypeptides, methods for making AAV9 vectors, and methods for using such vectors or molecules to treat cardiovascular and/or renal diseases are provided.

Claims (8)

1. A method for improving cardiac function in a mammal with polycystic kidney disease, wherein said method comprises administering an AAV8 vector to said mammal with polycystic kidney disease,

wherein said AAV8 vector comprises a nucleic acid sequence encoding a natriuretic polypeptide, and

wherein cardiac function is improved at least two months following said administration when said AAV8 vector is administered to said mammal with polycystic kidney disease.

2. The method of claim 1 , wherein said mammal is a human.

3. The method of claim 1 , wherein said natriuretic polypeptide is a human BNP polypeptide.

4. The method of claim 1 , wherein said natriuretic polypeptide is a CDNP polypeptide.

5. The method of claim 1 , wherein said natriuretic polypeptide is a B-CDNP polypeptide.

6. The method of claim 1 , wherein said natriuretic polypeptide is a C-CDNP polypeptide.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 7, 2018
From: IKEDA, YASUHIRO; RUSSELL, STEPHEN JAMES; CATALIOTTI, ALESSANDRO; BURNETT, JOHN C., JR.; TONNE, JASON M.
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 046020/0293 →
CONFIRMATORY LICENSE Recorded May 25, 2018
From: MAYO CLINIC ROCHESTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 046245/0976 →
Continuity (4)
Continuation 15436426 · Feb 17, 2017
Continuation 14370554
Provisional Application 61584006 · Jan 6, 2012
Related Publication 20180243378A1 · Aug 30, 2018