IP Library Granted Patent US 10,751,538
Granted Patent B2
US 10,751,538 · App. 15/969,418 · Granted Aug 25, 2020

Stimulation of a hypoglossal nerve for controlling the position of a patient's tongue

Inventors: Marcelo G. Lima (San Diego, CA); Paul M. Meadows (Glendale, CA); Jasper Benke (San Diego, CA)
Assignee: ImThera Medical, Inc.
A61N1/3611A61N1/0551A61N1/36139A61N1/36167A61N1/3787A61N1/0556
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Quick Facts
Patent No.
US 10,751,538
App. No.
15/969,418
Granted
Aug 25, 2020
Kind
B2
Abstract

A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's hypoglossal nerve, applying an electric signal through the electrode to the hypoglossal nerve to stimulate at least one muscle of the tongue at least until the number of obstructive sleep apnea occurrences are reduced from an initial level to a treatment level, and reducing the application of the electric signal while the number of obstructive sleep apnea occurrences remain generally at or below the treatment level.

Claims (25)

1. A method for controlling a position of a patient's tongue, the method comprising:

attaching at least one electrode to the patient's hypoglossal nerve;

applying an electric signal through the at least one electrode to the hypoglossal nerve to stimulate at least one muscle of the tongue at least until a number of obstructive sleep apnea occurrences are reduced from an initial level to a treatment level; and

reducing at least one parameter of the electric signal while the number of obstructive sleep apnea occurrences remain generally at or below the treatment level.

2. The method of claim 1 , wherein reducing the at least one parameter of the electric signal includes applying the electric signal having an Intra-Session Periodicity.

3. The method of claim 1 , wherein reducing the at least one parameter of the electric signal includes applying the electric signal having an Inter-Session Periodicity.

4. The method of claim 1 , wherein reducing the at least one parameter of the electric signal includes reducing a duration that the electric signal is applied.

5. The method of claim 1 , wherein reducing the at least one parameter of the electric signal includes ceasing application of the electric signal.

6. The method of claim 1 , wherein reducing the at least one parameter of the electric signal includes reducing a frequency at which the electrical signal is applied.

7. The method of claim 1 , wherein reducing the at least one parameter of the electric signal includes reducing an amplitude at which the electric signal is applied.

8. The method of claim 1 further comprises:

applying an initial electric signal that gradually increases over time and then levels off.

9. The method of claim 1 , wherein the electric signal is applied to at least one targeted motor efferent of the hypoglossal nerve.

10. The method of claim 1 , wherein the electric signal is applied when the patient is asleep.

11. The method of claim 1 , wherein the electric signal is applied when the patient is awake.

12. A method for controlling a position of a patient's tongue, the method comprising:

attaching at least one electrode to the patient's hypoglossal nerve;

applying an electric signal through the at least one electrode to the hypoglossal nerve at an Inter-Session Periodicity to stimulate at least one muscle of the tongue to reduce the number of obstructive sleep apnea occurrences.

13. A method for controlling a position of a patient's tongue, the method comprising:

attaching at least one electrode to the patient's hypoglossal nerve;

applying an electric signal through the at least one electrode to the hypoglossal nerve at an Intra-Session Periodicity to stimulate at least one muscle of the tongue to reduce the number of obstructive sleep apnea occurrences.

14. A system for controlling a position of a patient's tongue, the system comprising:

at least one electrode configured to attach to the patient's hypoglossal nerve; and

an implantable pulse generator programmed to perform a method according to claim 1 .

15. A non-transitory computer readable storage medium having stored thereon computer-executable instructions which, when executed by a processor, perform a method according to claim 1 .

Assignments (6)
RELEASE OF SECURITY INTEREST Recorded Sep 20, 2021
From: ACF FINCO I LP
To: IMTHERA MEDICAL, INC.
Reel/Frame 057535/0850 →
SECURITY INTEREST Recorded Aug 16, 2021
From: IMTHERA MEDICAL, INC.
To: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
Reel/Frame 057188/0115 →
RELEASE OF SECURITY INTEREST Recorded Aug 16, 2021
From: ARES CAPITAL CORPORATION, AS AGENT FOR THE LENDERS
To: IMTHERA MEDICAL, INC.
Reel/Frame 057188/0573 →
PATENT SECURITY AGREEMENT Recorded Dec 30, 2020
From: IMTHERA MEDICAL, INC.
To: ACF FINCO I LP, AS COLLATERAL AGENT
Reel/Frame 054881/0683 →
PATENT SECURITY AGREEMENT Recorded Jun 17, 2020
From: IMTHERA MEDICAL, INC.
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 052963/0651 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 2, 2018
From: LIMA, MARCELO G.; MEADOWS, PAUL M.; BENKE, JASPER
To: IMTHERA MEDICAL, INC.
Reel/Frame 045970/0171 →
Continuity (5)
Continuation 15499511 · Apr 27, 2017
Continuation 15058722 · Mar 2, 2016
Continuation 14400733
Provisional Application 61647122 · May 15, 2012
Related Publication 20180250509A1 · Sep 6, 2018