IP Library › Granted Patent US 10,434,108
Granted Patent B2
US 10,434,108 · App. 15/986,872 · Granted Oct 8, 2019

Synthetic bile acid compositions and methods

Inventors: Robert M. Moriarty (Michiana Shores, IN); Nathaniel E. David (Los Angeles, CA); Nadir Ahmeduddin Mahmood (Calabasas, CA)
Assignee: ALLERGAN SALES, LLC
A61K31/575A61K45/06C07J9/00Y10T436/201666
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Quick Facts
Patent No.
US 10,434,108
App. No.
15/986,872
Granted
Oct 8, 2019
Kind
B2
Abstract

Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.

Claims (6)

1. An aqueous pharmaceutical composition comprising about 0.1% w/v to about 2% w/v deoxycholic acid, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient and/or carrier, wherein the deoxycholic acid has a 14 C content of less than 1 ppt.

2. The composition of claim 1 , wherein the deoxycholic acid has a 14 C content of less than 0.9 ppt.

3. The composition of claim 1 , wherein the deoxycholic acid has a 14 C content of 0.87 ppt.

4. The composition of claim 1 , wherein the deoxycholic acid has a 14 C content of 0.88 ppt.

5. The composition of claim 1 , wherein the deoxycholic acid has a 14 C content of 0.89 ppt.

6. The composition of claim 1 which is suitable for subcutaneous injection.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 19, 2021
From: MORIARTY, ROBERT M.; DAVID, NATHANIEL E.; MAHMOOD, NADIR AHMEDUDDIN
To: KYTHERA BIOPHARMACEUTICALS, INC.
Reel/Frame 056904/0887 →
MERGER AND CHANGE OF NAME Recorded Aug 7, 2019
From: KYTHERA BIOPHARMACEUTICALS, LLC; ALLERGAN SALES, LLC
To: ALLERGAN SALES, LLC
Reel/Frame 049981/0654 →
CHANGE OF NAME Recorded Aug 3, 2019
From: KYTHERA BIOPHARMACEUTICALS, INC.
To: KYTHERA BIOPHARMACEUTICALS, LLC
Reel/Frame 049951/0877 →
Continuity (9)
Continuation 15472135 · Mar 28, 2017
Continuation 14732515 · Jun 5, 2015
Continuation 13914510 · Jun 10, 2013
Continuation 13486955 · Jun 1, 2012
Continuation 12541045 · Aug 13, 2009
Continuation In Part 12035339 · Feb 21, 2008
Provisional Application 60956875 · Aug 20, 2007
Provisional Application 60945035 · Jun 19, 2007
Related Publication 20180338987A1 · Nov 29, 2018