Compositions and methods for stimulation MAGP-1 to improve the appearance of skin
The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.
1. A composition comprising a MAGP-1 stimulating substance in a cosmetically acceptable vehicle, wherein the activity of said MAGP-1 stimulating substance has been identified by a MAGP-1 screening assay; wherein the composition is in the form of a cream, emulsion or lotion; and wherein the MAGP-1 active agent is present in an amount of from about 0.01 wt % to about 10 wt % of the total weight of the composition.
2. A composition for improving the aesthetic appearance of human skin comprising:
(i) a MAGP-1 active agent selected from the group consisting of:
an extract of Operculina turpethum,
an extract of Ixora chinensis,
an extract of Clerodendrum lindleyi,
a compound of formula II:
and combinations thereof; and
(ii) a cosmetically acceptable vehicle;
wherein the composition is in the form of a cream, emulsion or lotion.
3. The composition according to claim 2 , wherein the MAGP-1 active agent is present in an amount of from about 0.01 wt % to about 10 wt % of the total weight of the composition.
4. The composition according to claim 2 , comprising Operculina turpethum.
5. The composition according to claim 2 , comprising Ixora chinensis.
6. The composition according to claim 2 , comprising Clerodendrum linleyi.
7. The composition according to claim 2 , comprising a compound having the formula:
8. The composition according to claim 2 , further comprising a second MAGP-1 active agent selected from the group consisting of extracts of Sesbania grandiflora , extracts of Amorphophallus campanulatus , extracts of Sapindus rarak, extracts of Tiliacora triandra , extracts of Thumbergia laurifolia , a synthetic tetrapeptide lysine-threonine-phenylalanine-lysine, thiodipropionic acid and its C 1 -C 4 mono- and dialkyl esters, and combinations thereof.
9. The composition of claim 2 , wherein the cosmetically acceptable vehicle is in the form of an emulsion comprising an emulsifier in an amount from about 0.1% to about 30% by weight.
10. The composition of claim 9 , wherein the emulsion comprises a water-in-oil, oil-in-water, water-in-silicone, or silicone-in-water emulsion.
11. The composition of claim 2 , wherein the composition is in the form of a lotion or cream.
12. The composition according to claim 2 , wherein the cosmetically acceptable vehicle comprises one or more of glycerin, C1-4 alcohol, fatty alcohols, fatty ethers, fatty esters, polyols, glycols, vegetable oils, mineral oils, liposomes, laminar lipid materials, and silicone oils.
13. The composition of claim 2 , wherein the cosmetically acceptable vehicle comprises one or more of fatty esters, vegetable oils, and silicone oils.
14. A method for improving the condition or aesthetic appearance of human skin comprising topically applying to skin in need thereof an effective amount of a composition of claim 2 , wherein said improvement is selected from the group consisting of:
(a) treatment, reduction, and/or prevention of fine lines or wrinkles,
(b) reduction of skin pore size,
(c) improvement in skin thickness, plumpness, and/or firmness;
(d) improvement in skin suppleness and/or softness;
(e) improvement in skin tone, radiance, and/or clarity;
(f) improvement in procollagen and/or collagen production;
(g) improvement in maintenance and remodeling of elastin;
(h) improvement in skin texture and/or promotion of retexturization;
(i) improvement in skin barrier repair and/or function;
(j) improvement in appearance of skin contours;
(k) restoration of skin luster and/or brightness;
(l) replenishment of essential nutrients and/or constituents in the skin;
(m) improvement of skin appearance decreased by menopause;
(n) improvement in skin moisturization;
(o) increase in skin elasticity and/or resiliency;
(p) treatment, reduction, and/or prevention of skin sagging; and
(r) reduction of pigment spots; or any combination thereof.
15. The method according to claim 14 , wherein said improvement is the treatment, reduction, and/or prevention of fine lines or wrinkles.
16. The method according to claim 14 , wherein said improvement is an increase in skin elasticity and/or resiliency.
17. The method according to claim 14 , wherein said improvement is the treatment, reduction, and/or prevention of skin sagging.
18. The method according to claim 14 , wherein the composition is topically applied at least once daily for at least one week.