IP Library › Granted Patent US 11,123,416
Granted Patent B2
US 11,123,416 · App. 16/016,473 · Granted Sep 21, 2021

Methods and compositions relating to synthetic beta-1,6 glucosamine oligosaccharides

Inventors: Gerald B. Pier (Brookline, MA); Nikolay Nifantiev (Moscow, RU); Yury Tsvetkov (Moscow, RU); Marina Gening (Moscow, RU)
Assignee: The Brigham and Women's Hospital, Inc.
A61K39/085A61K47/646A61K47/6415C07C327/32C07D207/46C07H3/06C07K16/1232C07K16/1271A61K2039/55A61K2039/552A61K2039/575A61K2039/6037C07K2317/33Y02A50/30
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Quick Facts
Patent No.
US 11,123,416
App. No.
16/016,473
Granted
Sep 21, 2021
Kind
B2
Abstract

The invention relates to the compositions of synthetic oligo-β-(1→6)-2-amino-2-deoxy-D-glu-copyranosides conjugated to carriers, and methods for making and use same.

Claims (6)

1. An oligosaccharide-carrier conjugate comprising an oligosaccharide conjugated to a carrier that is tetanus toxoid, through a linker, wherein the oligosaccharide is a β-1,6-linked glucosamine that is 0-40% acetylated and 5-11 monomers in length.

2. The oligosaccharide-carrier conjugate of claim 1 , wherein the oligosaccharide is 5 monomers in length.

3. The oligosaccharide-carrier conjugate of claim 1 , wherein the oligosaccharide is 0% acetylated.

4. The oligosaccharide-carrier conjugate of claim 1 , wherein the oligosaccharide-carrier conjugate has an oligosaccharide to carrier ratio of 1:1, 2:1, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1, 9:1, 10:1, 20:1, 30:1, 40:1, 50:1, 60:1, 70:1, 80:1, 90:1 or 100:1.

5. The oligosaccharide-carrier conjugate of claim 1 , wherein the oligosaccharide-carrier conjugate has an oligosaccharide to carrier ratio in the range of 10:1 to 50:1.

6. The oligosaccharide-carrier conjugate of claim 1 , free of microbial contaminants other than tetanus toxoid or components thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 19, 2018
From: PIER, GERALD B.; NIFANTIEV, NIKOLAY; TSVETKOV, YURY; GENING, MARINA
To: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 047232/0969 →
Continuity (6)
Continuation 15258417 · Sep 7, 2016
Continuation 13924435 · Jun 21, 2013
Division 13055178
Provisional Application 61208155 · Feb 20, 2009
Provisional Application 61135493 · Jul 21, 2008
Related Publication 20190117754A1 · Apr 25, 2019
Cited By (1)
US 12,397,014