Method for treating hyperhidrosis with dexmecamylamine
The present invention relates to dexmecamylamine and the use of dexmecamylamine, substantially free of exo-R-mecamylamine, in the treatment of hyperhidrosis.
1. A method of treating hyperhidrosis, the method comprising the administration of a therapeutically effective amount of dexmecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-R-mecamylamine, to a subject with hyperhidrosis.
2. The method of claim 1 , wherein the administration of dexmecamylamine or a pharmaceutically acceptable salt thereof substantially free of exo-R-mecamylamine, is once daily.
3. The method according to claim 1 , wherein the dexmecamylamine or a pharmaceutically acceptable salt thereof is orally administered in an amount of about 4 mg.
4. The method according to claim 1 , wherein the dexmecamylamine or a pharmaceutically acceptable salt thereof is orally administered in an amount of about 0.5 mg.
5. The method according to claim 1 , wherein the dexmecamylamine or a pharmaceutically acceptable salt thereof is orally administered in an amount of about 1.0 mg.
6. The method according to claim 1 , wherein the dexmecamylamine or a pharmaceutically acceptable salt thereof is orally administered in an amount of about 2.0 mg.
7. The method according to claim 1 , wherein the dexmecamylamine or a pharmaceutically acceptable salt thereof is orally administered in tablet form.
8. The method of claim 1 , wherein the administration of dexmecamylamine is sufficient to affect sweating in a patient in at least one location with an Hyperhidrosis Disease Severity Scale change of ≥1.
9. The method according to claim 8 , wherein the administration of dexmecamylamine is sufficient to affect sweating in a patient in at least two locations with an HDSS change of ≥0.5, in each location.
10. The method according to claim 8 , wherein the location is selected from axillary, palmoplantar, face/scalp, or generalized.
11. The method according to claim 1 , wherein the hyperhidrosis is primary hyperhidrosis.
12. The method according to claim 1 , wherein the subject is a human.
13. The method of claim 1 , wherein the dexmecamylamine or a pharmaceutically acceptable salt thereof is administered more than once daily.
14. The method of claim 1 , wherein the hyperhidrosis is palmoplantar.
15. The method of claim 6 , wherein the dexmecamylamine or pharmaceutically acceptable salt thereof is administered more than once daily.
16. The method of claim 1 , wherein the hyperhidrosis is secondary hyperhidrosis.
17. The method of claim 1 , wherein the hyperhidrosis is secondary to spinal cord injury.
18. The method of claim 1 , wherein the hyperhidrosis results from increased sympathetic cholinergic activity.