Diagnosis and treatment of tissue

1. A method of evaluating a three dimensional image of at least a portion of a prostate of a patient, the method comprising:

positioning an optical probe configured to target a location within the prostate of the patient;

transmitting light from the optical probe toward the location and receiving fluorescence spectra by the optical probe from the location;

generating, by a tissue classification system, a diagnosis classification indicative of tissue condition of tissue at the location, the tissue classification system executing at least one algorithm that generates the diagnosis classification based only on selected data of the fluorescence spectra from the location; and

generating a visual display of the image of the prostate and the diagnosis classification overlapping the image at the location so as to confirm or contradict the existence of a cancer lesion at the location.

2. A method as in claim 1 , wherein the image comprises a magnetic resonance imaging (MRI) image, an ultrasound (US) image, or a computed tomography (CT) image or a multimodality (MMI image.

3. A method as in claim 1 , wherein the image comprises an MRI/US fusion image.

4. A method as in claim 1 , wherein the diagnosis classification is visualized on the visual display by a color indicating the diagnosis classification.

5. A method as in claim 1 , further comprising selecting an option for the visual display, wherein the option comprises a black-and-white image, a color image, and/or a line image.

6. A method as in claim 1 , wherein positioning the probe comprises introducing the probe under ultrasound, MRI or CT guidance.

7. A method as in claim 1 , wherein the optical probe includes a biopsy needle, the method further comprising deploying the biopsy needle so af, configured to biopsy the location within the prostate if the visual display of the diagnosis classification confirms the existence of the cancer lesion at the location.

8. A method as in claim 7 , wherein deploying the biopsy needle comprises activating an auto needle advancing mechanism.

9. A method as in claim 1 , wherein the optical probe includes a treatment modality, the method further comprising activating the treatment modality so as to treat the location within the prostate if the visual display of the diagnosis classification confirms the existence of the cancer lesion at the location.

10. A method as in claim 9 , wherein the treatment modality comprises cryotherapy, photodynamic therapy, brachytherapy, high-intensity focused ultrasound (HIFU) therapy, ablation therapy, laser ablation therapy, radio frequency (RFI ablation therapy, vapor ablation therapy or local drug delivery.

11. A method as in claim 1 , wherein the image indicates a plurality of locations within the prostate of the patient having potential presence of cancer lesions, the method further comprising repeating the method of evaluating the image at each of the plurality of locations.

12. A method as in claim 11 , wherein the optical probe includes a biopsy needle, the method further comprising deploying the biopsy needle so af, configured to biopsy each of the plurality of locations having a correlated visual display of diagnosis classification confirming the existence of the cancer lesion and skipping deploying the biopsy needle at each of the plurality of locations having a correlated visual display of diagnosis classification contradicting the existence of the cancer lesion.

13. A method as in claim 11 , wherein the optical probe includes a treatment modality, the method further comprising activating the treatment modality so as to treat each of the plurality of locations having a correlated visual display of diagnosis classification confirming the existence of the cancer lesion and skipping activating the treatment modality at each of the plurality of locations having a correlated visual display of diagnosis classification contradicting the existence of the cancer lesion.

14. A method as in claim 1 , wherein the fluorescence spectra is generated from endogenous fluorophores.

15. A method as in claim 14 , wherein the endogenous fluorophores comprise amino acids, tryptophan, tyrosine, phenylalanine, structural proteins, collagen, elastin, enzymes, coenzymes, flavin adenine dinucleotide (FAD), flavins, nicotinamide adenine dinucleotide (NADH), nicotinamide adenine dinucleotide phosphate (NADPH), vitamins, vitamin A, vitamin K, vitamin D, vitamin B6, compounds, pyridoxine, pyridoxamone, pyridoxal, pyridoxic acid, pyridoxal 5′-phosphate, vitamin B12, lipids, phospholipids, lipofuscin, ceroid, and/or porphyrins.

16. A method as in claim 1 , wherein the image indicates a potential presence of a cancer lesion at at least one additional location within the prostate of the patient, the method further comprising

re-positioning the optical probe configured to target the at least one additional location within the prostate of the patient,

transmitting light from the optical probe toward the at least one additional location and receiving fluorescence spectra by the optical probe from the at least one additional location,

generating, by the tissue classification system, an additional diagnosis classification indicative of tissue condition of tissue at the at least one additional location, the tissue classification system executing the at least one algorithm that generates the additional diagnosis classification based only on selected data of the fluorescence spectra from the at least one additional location, and

generating a visual display of the additional diagnosis classification overlapping the image at the at least one additional location so as to confirm or contradict the existence of the cancer lesion at the at least one additional location.