IP Library Granted Patent US 10,273,249
Granted Patent B2
US 10,273,249 · App. 16/033,464 · Granted Apr 30, 2019

5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative

Inventors: Simon Fraser Hunt (Nottingham, GB); Stuart Thomas Onions (Nottingham, GB); Vladimir Sherbukhin (Nottingham, GB); Euan Alexander Fraser Fordyce (Nottingham, GB); Peter John Murray (London, GB); Daniel William Brookes (London, GB); Kazuhiro Ito (London, GB); Peter Strong (London, GB); Matthew Stephen Coates (London, GB)
Assignee: PULMOCIDE LIMITED
C07D519/00A61K9/10A61K9/14A61K31/55A61K45/06C07D495/04
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Quick Facts
Patent No.
US 10,273,249
App. No.
16/033,464
Granted
Apr 30, 2019
Kind
B2
Abstract

There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (1)).

Claims (8)

1. A compound of formula (VI)

or a salt thereof.

2. A compound of formula (X)

wherein LG is a leaving group and R a is lower alkyl;

or a salt thereof.

3. The compound according to claim 2 , wherein the leaving group is a halogen atom.

4. The compound according to claim 3 wherein the halogen atom is chlorine.

5. The compound according to claim 2 wherein R a is ethyl.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 12, 2018
From: HUNT, SIMON FRASER; ONIONS, STUART THOMAS; SHERBUKHIN, VLADIMIR; FORDYCE, EUAN ALEXANDER FRASER; MURRAY, PETER JOHN; COATES, MATTHEW STEPHEN; BROOKES, DANIEL WILLIAM; ITO, KAZUHIRO; STRONG, PETER; SYGNATURE DISCOVERY LTD
To: PULMOCIDE LIMITED
Reel/Frame 046330/0794 →
Priority Claims (1)
EP 14188494 · Oct 10, 2014 · regional
Continuity (4)
Continuation 15902077 · Feb 22, 2018
Continuation 15642637 · Jul 6, 2017
Continuation 15305003
Related Publication 20180319820A1 · Nov 8, 2018