Delivery system comprising a core and a digestible polymer shell
View Patent ↗A delivery vehicle with a core surrounded by a digestible polymer shell having a melting and/or softening point above the body temperature of an animal or human, and where the core has a lipid and/or lipophilic active ingredient dispersed in a continuous polymer matrix. The delivery vehicle can be used to release lipid and/or lipophilic active ingredients, such as pharmaceuticals, nutraceuticals, supplements, traditional/herbal medicine, or combinations thereof, after a predetermined lag time following ingestion.
1. A delivery vehicle comprising a core surrounded by a digestible polymer shell having a melting and/or softening point above the body temperature of an animal or human, wherein the core comprises a lipid and/or lipophilic active ingredient dispersed in a continuous polymer matrix, and wherein the digestible polymer comprised within the digestible polymer shell is a cross linked digestible biopolymer.
2. The delivery vehicle according to claim 1 , wherein the polymer matrix is solid below the body temperature of an animal or human and a solid or a liquid at or above the body temperature of an animal or human.
3. The delivery vehicle according to claim 1 , wherein the polymer matrix is a biopolymer matrix and wherein the biopolymer is selected from the group consisting of: gelatine, carrageenans, pectin, alginates, agar, gellan, konjac mannan, guar gum, gellan gum, locust bean gum, and combinations thereof.
4. The delivery vehicle according to claim 1 , wherein the lipid and/or lipophilic active ingredient is selected from the group consisting of: a pharmaceutical, nutraceutical, supplement, veterinary drug, natural/traditional medicine, food ingredient, and combinations thereof.
5. A delivery vehicle comprising a core surrounded by a digestible polymer shell having a melting and/or softening point above the body temperature of an animal or human,
wherein the core comprises a lipid and/or lipophilic active ingredient dispersed in a continuous polymer matrix,
wherein the digestible polymer comprised within the digestible polymer shell is a cross linked digestible biopolymer, and
wherein the lipid and/or lipophilic active ingredient is selected from the group consisting of: triglycerides, phospholipids, diglycerides, monoglycerides, ceramides, glycolipids and sphingolipids, fish oil, petroselinic acid, eicosapentaenoic acid, carotenoids, phytosterols, phytosterol esters, polyphenols, cholesterol, cholesterol esters, retinol, retinol ester, and combinations thereof.
6. A delivery vehicle comprising a core surrounded by a digestible polymer shell having a melting and/or softening point above the body temperature of an animal or human,
wherein the core comprises a lipid and/or lipophilic active ingredient dispersed in a continuous polymer matrix,
wherein the digestible polymer comprised within the digestible polymer shell is a cross linked digestible biopolymer, and
wherein the core contains an emulsifier.
7. The delivery vehicle according to claim 1 , wherein the digestible polymer shell is formed from one or more biopolymer selected from the group consisting of: Bovine serum albumin, β-lactoglobulin, lactoferrin, whey protein isolate patatin, soy protein, canola protein, pea protein, egg protein, lysozyme, pea proteins, lupin, rice protein, gluten, lysozyme, zein, and combinations thereof.
8. A delivery vehicle comprising a core surrounded by a digestible polymer shell having a melting and/or softening point above the body temperature of an animal or human,
wherein the core comprises a lipid and/or lipophilic active ingredient dispersed in a continuous polymer matrix,
wherein the digestible polymer comprised within the digestible polymer shell is a cross linked digestible biopolymer, and
wherein the digestible polymer shell has an average mesh/pore size of <50 nm.
9. A delivery vehicle comprising a core surrounded by a digestible polymer shell having a melting and/or softening point above the body temperature of an animal or human,
wherein the core comprises a lipid and/or lipophilic active ingredient dispersed in a continuous polymer matrix,
wherein the digestible polymer comprised within the digestible polymer shell is a cross linked digestible biopolymer, and
wherein the core comprises a weighting agent and/or wherein the digestible polymer shell comprises a thickener.
10. A delivery vehicle comprising a core surrounded by a digestible polymer shell having a melting and/or softening point above the body temperature of a subject,
wherein the core comprises a lipid and/or lipophilic active ingredient dispersed in a continuous polymer matrix,
wherein the digestible polymer comprised within the digestible polymer shell is a cross linked digestible biopolymer, and
wherein 50% or more of the lipid and/or lipophilic active ingredient is released within 45 minutes or less and/or 80% or more of the lipid and/or lipophilic active ingredient is release within 75 minutes or less following the expiry of a predetermined lag time following ingestion of said delivery vehicle by the subject.
11. A consumable product comprising a delivery vehicle comprising a core surrounded by a digestible polymer shell having a melting and/or softening point above the body temperature of a subject, wherein the core comprises a lipid and/or lipophilic active ingredient dispersed in a continuous polymer matrix, and wherein the digestible polymer comprised within the digestible polymer shell is a cross linked digestible biopolymer, the composition and/or consumable product is selected from the group consisting of; pharmaceutical products, nutraceutical products, medical foods, veterinary products including pet food and pet care products and, foodstuffs of any kind including functional foods and food supplements.
12. The consumable product according to claim 11 , wherein the lipid and/or lipophilic active ingredient is selected from the group consisting of: triglycerides, phospholipids, diglycerides, monoglycerides, ceramides, glycolipids and sphingolipids, fish oil, petroselinic acid, eicosapentaenoic acid, carotenoids, phytosterols, phytosterol esters, polyphenols, cholesterol, cholesterol esters, retinol, retinol ester, and combinations thereof.
13. The consumable product according to claim 11 , wherein the core contains an emulsifier.
14. The consumable product according to claim 11 , wherein the digestible polymer shell has an average mesh/pore size of <50 nm.
15. The consumable product according to claim 11 , wherein the core comprises a weighting agent and/or wherein the digestible polymer shell comprises a thickener.
16. The consumable product according to claim 11 , wherein 50% or more of the lipid and/or lipophilic active ingredient is released within 45 minutes or less and/or 80% or more of the lipid and/or lipophilic active ingredient is release within 75 minutes or less following the expiry of a predetermined lag time following ingestion of said delivery vehicle by the subject.
17. The consumable product according to claim 11 , wherein the cross linked digestible biopolymer is a thermally cross linked digestible biopolymer.
18. The delivery vehicle according to claim 1 , wherein the cross linked digestible biopolymer is a thermally cross linked digestible biopolymer.
19. The delivery vehicle according to claim 5 , wherein the cross linked digestible biopolymer is a thermally cross linked digestible biopolymer.
20. The delivery vehicle according to claim 6 , wherein the cross linked digestible biopolymer is a thermally cross linked digestible biopolymer.
21. The delivery vehicle according to claim 8 , wherein the cross linked digestible biopolymer is a thermally cross linked digestible biopolymer.
22. The delivery vehicle according to claim 9 , wherein the cross linked digestible biopolymer is a thermally cross linked digestible biopolymer.
23. The delivery vehicle according to claim 10 , wherein the cross linked digestible biopolymer is a thermally cross linked digestible biopolymer.