Benzothiazole amphiphiles
View Patent ↗Disclosed herein, inter alia, are compounds and methods for increasing spine density in a neuron, and for treatment of neuronal diseases and cancer.
1. A compound having the formula (I):
wherein
R 1 is independently
halogen, —CX 1 3 , —CHX 1 2 , —CH 2 X 1 , —OCX 1 3 , —OCHX 1 2 , —OCH 2 X 1 , —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , NHC(O)NH 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
R 2 is independently
halogen, —CX 2 3 , —CHX 2 2 , —CH 2 X 2 , —OCX 2 3 , —OCHX 2 2 , —OCH 2 X 2 , —CN, —OH, —NH 2 , —COOH, —CONH 2 , —NO 2 , —SH, —SO 3 H, —SO 4 H, —SO 2 NH 2 , —NHNH 2 , —ONH 2 , —NHC(O)NHNH 2 , —NHC(O)NH 2 , —NHSO 2 H, —NHC(O)H, —NHC(O)OH, —NHOH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
X 1 and X 2 are independently halogen;
z1 and z2 are independently an integer from 0 to 4; and
n is an integer from 1 to 12.
2. The compound of claim 1 , wherein R 1 is substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
3. The compound of claim 1 , wherein R 1 is substituted or unsubstituted alkyl.
4. The compound of claim 1 , wherein R 2 is substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
5. The compound of claim 1 , wherein R 2 is substituted or unsubstituted alkyl.
6. The compound of claim 1 , wherein z1 is 0 or 1.
7. The compound of claim 1 , wherein z1 is 0.
8. The compound of claim 1 , wherein z2 is 0.
9. The compound of claim 1 , wherein n is 3 to 8.
10. The compound of claim 1 , wherein n is 3 to 5.
11. The compound of claim 1 , having the formula:
12. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of claim 1 .