Anti-tenascin C antibodies and uses thereof
There is provided antibodies or antigen-binding fragments, derivatives or variants thereof which are capable of binding to the FBG domain of tenascin-C. There are also provided uses of such antibodies or antigen-binding fragments, derivatives or variants thereof, as well as methods of identifying such antibodies.
1. An anti-fibrinogen-like globe (FBG) domain of tenascin-C antibody or antigen-binding fragment thereof comprising a VH region and a VL region, wherein the VH region comprises SEQ ID NO: 37 and wherein the VL region comprises RASQYIQGFLN (SEQ ID NO: 5) for CDRL1, DASNLET (SEQ ID NO: 13) for CDRL2, and QQSYSTPQT (SEQ ID NO: 14) for CDRL3.
2. A composition comprising an antibody or antigen-binding fragment of claim 1 and a pharmaceutically acceptable carrier, excipient and/or diluent.
3. A method of treating rheumatoid arthritis comprising administering to a subject an effective amount of an antibody or antigen-binding fragment according to claim 1 .