The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising these polypeptides. The invention further provides compositions for use in treating, preventing or detecting a bacterial infection, in particular vaccine compositions using the antigenic polypeptides. The invention further provides antibodies directed to said antigenic polypeptides.
1. A method of producing an antibody protective against Acinetobacter baumannii , the method comprising:
introducing a polypeptide comprising the sequence of SEQ ID NO: 8 into a mammal along with an adjuvant; and,
isolating the protective antibody;
wherein the antibody binds to the motif FEDFN (SEQ ID NO.: 37) and induces an effector function towards Acinetobacter baumannii.
2. The method of claim 1 , wherein the antibody is polyclonal.