Pharmaceutical compositions comprising perillyl alcohol derivatives
A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.
1. A method for treating a cancer in a mammal, comprising the step of administering to the mammal a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I,
wherein R is selected from the group consisting of a C 4 to C 28 linear or branched alkyl, linear or branched C 4 to C 28 alkeneyl and a linear or branched C 4 to C 28 alkynyl group; or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the cancer is a tumor of the nervous system.
3. The method of claim 2 , wherein the tumor is a glioblastoma.
4. The method of claim 1 , wherein the cancer is a skin cancer selected from the group of melanoma, basal cell carcinoma, and squamous cell carcinoma.
5. The method of claim 4 , wherein the cancer is melanoma.
6. The method of claim 1 , wherein the pharmaceutical composition is administered by inhalation, intranasally, orally, intravenously, topically, transdermally, subcutaneously or intramuscularly.
7. The method of claim 6 , wherein the pharmaceutical composition is administered topically.
8. The method of claim 1 , wherein R is a C 4 to C 28 linear or branched alkeneyl containing 1, 2, 3, 4 or 5 double bonds, or a linear or branched C 4 to C 28 alkynyl group containing 1, 2, 3, 4 or 5 triple bonds.
9. The method of claim 1 , wherein the compound is of Formula II,
or a pharmaceutically acceptable salt thereof.