IP Library › Granted Patent US 10,255,997
Granted Patent B2
US 10,255,997 · App. 16/140,374 · Granted Apr 9, 2019

Medical analytics system

Inventors: Michael E. Calhoun (Seattle, WA); Samir Chowdhury (La Jolla, CA); Ilya Goldberg (Seattle, WA)
Assignee: Mindshare Medical, Inc.
G16H50/20A61B6/488G06T7/0012G06T7/168G06K9/522G16H30/00G16H50/30G16H80/00
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Quick Facts
Patent No.
US 10,255,997
App. No.
16/140,374
Filed
Sep 24, 2018
Granted
Apr 9, 2019
Kind
B2
Examiner
PARK, EDWARD
Art Unit
2666
USPC
382/128
Abstract

Systems and methods of a medical analytics system are described herein. The medical analytics system can include a machine learning model for processing patient tissue images for either training the machine learning model or for clinical use, such as providing information for assisting a clinician with at least diagnosing a disease or condition of a patient. Implementations of the medical analytics system can further include a user interface that is configured to allow a user to interact with a patient image for assisting with diagnosing at least a part of the tissue captured in the patient image.

Claims (56)

1. A system, comprising:

at least one processor; and

at least one memory including program code which when executed by the at least one processor provides operations comprising:

projecting a three-dimensional image of a patient tissue into a plurality of two-dimensional grayscale images;

applying at least one transformation algorithm to a first set of two-dimensional grayscale images to generate a first set of transformed two-dimensional grayscale images;

applying at least one feature algorithm to at least one two-dimensional grayscale image and to each transformed two-dimensional grayscale images of the first set of transformed two-dimensional grayscale images;

generating, based on the applying of the at least one feature algorithm to at least one two-dimensional grayscale image and to each transformed two-dimensional grayscale images, a plurality of feature values comprising a feature vector;

projecting the three-dimensional image into a two-dimensional color image;

applying at least one color transformation algorithm to a first set of two-dimensional color images to generate a first set of color-transformed two-dimensional grayscale images;

applying at least one feature algorithm to at least one two-dimensional color image and to each color-transformed two-dimensional grayscale images;

generating, based on the applying of the at least one feature algorithm to the at least one two-dimensional color image and to each of the transformed two-dimensional color images, a plurality of color feature values comprising the feature vector;

collecting patient information;

generating, based on the collected patient information, one or more patient values comprising the feature vector;

training a machine learning model based on the feature vector and an associated diagnosis of the patient tissue, the machine learning model comprising a classifier having a weighted value assigned to each of the plurality of feature values, the plurality of color feature values, and the patient value.

2. The system of claim 1 , further comprising:

defining, based on the training, a bio-marker that identifies one or more of the color value, the patient value, and at least one of the plurality of feature values, the bio-marker being part of the trained classifier for determining a diagnosis of an undiagnosed tissue captured in an undiagnosed three-dimensional image.

3. The system of claim 2 , wherein the diagnosis includes whether the undiagnosed tissue is malignant or benign.

4. The system of claim 2 , wherein the undiagnosed tissue is lung tissue or breast tissue.

5. The system of claim 1 , wherein the three-dimensional image includes a part of a captured three-dimensional image generated by a three-dimensional imaging system.

6. The system of claim 1 , wherein the three-dimensional image is projected onto at least two different dimensional planes thereby generating at least two different two-dimensional grayscale images.

7. A computer-implemented method, comprising:

projecting a three-dimensional image of a patient tissue into a plurality of two-dimensional grayscale images;

applying at least one transformation algorithm to a first set of two-dimensional grayscale images to generate a first set of transformed two-dimensional grayscale images;

applying at least one feature algorithm to at least one two-dimensional grayscale image and to each transformed two-dimensional grayscale images of the first set of transformed two-dimensional grayscale images;

generating, based on the applying of the at least one feature algorithm to at least one two-dimensional grayscale image and to each transformed two-dimensional grayscale images, a plurality of feature values comprising a feature vector;

projecting the three-dimensional image into a two-dimensional color image;

applying at least one color transformation algorithm to a first set of two-dimensional color images to generate a first set of color-transformed two-dimensional grayscale images;

applying at least one feature algorithm to at least one two-dimensional color image and to each color-transformed two-dimensional grayscale images;

generating, based on the applying of the at least one feature algorithm to the at least one two-dimensional color image and to each of the transformed two-dimensional color images, a plurality of color feature values comprising the feature vector;

collecting patient information;

generating, based on the collected patient information, one or more patient values comprising the feature vector;

training a machine learning model based on the feature vector and an associated diagnosis of the patient tissue, the machine learning model comprising a classifier having a weighted value assigned to each of the plurality of feature values, the plurality of color feature values, and the patient value.

8. The computer-implemented method of claim 7 , further comprising:

defining, based on the training, a bio-marker that identifies one or more of the color value, the patient value, and at least one of the plurality of feature values, the bio-marker being part of the trained classifier for determining a diagnosis of an undiagnosed tissue captured in an undiagnosed three-dimensional image.

9. The computer-implemented method of claim 8 , wherein the diagnosis includes whether the undiagnosed tissue is malignant or benign.

10. The computer-implemented method of claim 8 , wherein the undiagnosed tissue is lung tissue or breast tissue.

11. The computer-implemented method of claim 7 , wherein the three-dimensional image includes a part of a captured three-dimensional image generated by a three-dimensional imaging system.

12. The computer-implemented method of claim 7 , wherein the three-dimensional image is projected onto at least two different dimensional planes thereby generating at least two different two-dimensional grayscale images.

13. A non-transitory computer-readable storage medium including program code which when executed by at least one processor causes operations comprising:

projecting a three-dimensional image of a patient tissue into a plurality of two-dimensional grayscale images;

applying at least one transformation algorithm to a first set of two-dimensional grayscale images to generate a first set of transformed two-dimensional grayscale images;

applying at least one feature algorithm to at least one two-dimensional grayscale image and to each transformed two-dimensional grayscale images of the first set of transformed two-dimensional grayscale images;

generating, based on the applying of the at least one feature algorithm to at least one two-dimensional grayscale image and to each transformed two-dimensional grayscale images, a plurality of feature values comprising a feature vector;

projecting the three-dimensional image into a two-dimensional color image;

applying at least one color transformation algorithm to a first set of two-dimensional color images to generate a first set of color-transformed two-dimensional grayscale images;

applying at least one feature algorithm to at least one two-dimensional color image and to each color-transformed two-dimensional grayscale images;

generating, based on the applying of the at least one feature algorithm to the at least one two-dimensional color image and to each of the transformed two-dimensional color images, a plurality of color feature values comprising the feature vector;

collecting patient information;

generating, based on the collected patient information, one or more patient values comprising the feature vector;

training a machine learning model based on the feature vector and an associated diagnosis of the patient tissue, the machine learning model comprising a classifier having a weighted value assigned to each of the plurality of feature values, the plurality of color feature values, and the patient value.

14. The computer-readable storage medium of claim 13 , further comprising:

defining, based on the training, a bio-marker that identifies one or more of the color value, the patient value, and at least one of the plurality of feature values, the bio-marker being part of the trained classifier for determining a diagnosis of an undiagnosed tissue captured in an undiagnosed three-dimensional image.

15. The computer-readable storage medium of claim 14 , wherein the diagnosis includes whether the undiagnosed tissue is malignant or benign.

16. The computer-readable storage medium of claim 14 , wherein the undiagnosed tissue is lung tissue or breast tissue.

17. The computer-readable storage medium of claim 13 , wherein the three-dimensional image includes a part of a captured three-dimensional image generated by a three-dimensional imaging system.

18. The computer-readable storage medium of claim 13 , wherein the three-dimensional image is projected onto at least two different dimensional planes thereby generating at least two different two-dimensional grayscale images.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 29, 2021
From: MINDSHARE MEDICAL, INC.
To: PRECISION MEDICAL VENTURES, INC.
Reel/Frame 056085/0033 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 26, 2018
From: CALHOUN, MICHAEL E.; CHOWDHURY, SAMIR; GOLDBERG, ILYA
To: MINDSHARE MEDICAL, INC.
Reel/Frame 046983/0672 →
Continuity (3)
Continuation 16077994
Provisional Application 62361421 · Jul 12, 2016
Related Publication 20190027252A1 · Jan 24, 2019
Cited By (1)
US 12,475,564