Surfactant peptide nanostructures and uses thereof in drug delivery
Disclosed herein are surfactant peptide nanostructures wherein the peptides have repeating hydrophobic amino acids in an integer equal to or less than four. The peptide nanostructures are useful for therapeutic applications, including for delivery of drugs and siRNA.
1. A composition comprising a peptide having a nanospheric structure, wherein the peptide comprises the amino acid sequence of AAAAK (SEQ ID NO: 5) or AAAKAAA (SEQ ID NO: 15) wherein the peptide is present at a concentration of at least 0.01% (w/v) in an aqueous solution that has a pH from 6 to 8.
2. The composition of claim 1 , wherein the aqueous solution is at an ionic strength of up to 0.3 M.
3. The composition of claim 1 , wherein the aqueous solution is isotonic.
4. The composition of claim 1 , for use in drug delivery.
5. The composition of claim 4 , further comprising an agent for delivery to a subject.
6. The composition of claim 5 , wherein the agent is a therapeutic, a drug, or an siRNA.
7. The composition of claim 6 , wherein the siRNA is for delivery to a cancer cell.
8. The composition of claim 1 , wherein each amino acid is a D-amino acid.
9. The composition of claim 1 , wherein any of the peptides is amidated at the C-terminus and acetylated at the N-terminus.
10. The composition of claim 9 , wherein the peptide comprises the amino acid sequence of AAAAK (SEQ ID NO: 5).
11. The composition of claim 9 , wherein the peptide comprises the amino acid sequence of AAAKAAA (SEQ ID NO: 15).
12. A method of formulating an agent for delivery to a subject, the method comprising a step of contacting the agent with a composition according to claim 5 .
13. A method of delivering an agent to a subject, the method comprising administering to the subject a composition according to claim 1 .