Granted Patent
B2
US 12,239,744 · App. 17/722,357 · Granted Mar 4, 2025
Surfactant peptide nanostructures and uses thereof in drug delivery
Assignee:
3-D Matrix, Ltd.
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Abstract
Disclosed herein are surfactant peptide nanostructures wherein the peptides have repeating hydrophobic amino acids in an integer equal to or less than four. The peptide nanostructures are useful for therapeutic applications, including for delivery of drugs and siRNA.
Claims (6)
1. A drug delivery composition, said drug delivery composition comprising a peptide that consists of the amino acid sequence of AAAK (SEQ ID NO:1), wherein the peptide is present at a concentration of at least 0.01% (w/v) in an aqueous solution that has a pH from about 6 to about 8, and wherein the peptide is complexed with an siRNA.
2. The drug delivery composition of claim 1 , wherein the aqueous solution is at an ionic strength of up to 0.3 M.
3. The drug delivery composition of claim 1 , wherein the aqueous solution is isotonic.
4. The drug delivery composition of claim 1 , wherein the siRNA is for delivery to a cancer cell.
5. The drug delivery composition of claim 1 , wherein each amino acid is a D-amino acid.
6. The drug delivery composition of claim 1 , wherein the peptide is amidated at the C-terminus and acetylated at the N-terminus.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 19, 2022
From: GIL, EUN SEOK; ALEKSI, ELTON; MATSUDA, NORIAKI
To: 3-D MATRIX, LTD.
Reel/Frame 059635/0893 →
Continuity (3)
Provisional Application
62599566
· Dec 15, 2017
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