Apparatus and process for providing a coiled collagen carrier
The present invention relates inter alia to an apparatus for providing a coiled collagen carrier. An apparatus according to the invention preferably comprises a device for applying moisture to a collagen carrier prior to coiling of the collagen carrier and a coiling device. The coiling device preferably comprises rotatable gripping means for gripping the collagen carrier along an edge and coiling the collagen carrier, and a support device supporting the collagen carrier while being coiled. In another aspect, the invention relates to a production facility wherein an apparatus according to invention is arranged.
1. A process for coiling a collagen carrier comprising (i) a collagen layer and (ii) a coating layer comprising fibrinogen and thrombin, said process comprising the sequential steps of:
humidifying at least part of said collagen carrier;
coiling said collagen carrier by a rotating gripping means in one of a plurality of tray cavities each provided for a respective one of the coiled collagen carrier; and
drying the coiled collagen carrier by transporting the tray through a drying means, so as to provide a form-stable coiled collagen carrier configured for application to a patient.
2. The process according to claim 1 , wherein at least the coating layer of said collagen carrier is humidified by said humidifying.
3. The process according to claim 2 , wherein the coating layer has been humidified by said humidifying using a solvent.
4. The process according to claim 3 , wherein the collagen carrier is humidified on the coating layer by the solvent in an amount 1.2-10.75 mg/cm 2 surface of the coating layer.
5. The process according to 54, wherein the solvent comprises ethanol.
6. The method according to claim 3 , wherein the solvent consists of ethanol.
7. The process according to claim 1 , wherein the collagen carrier is compressed subsequently to said humidifying and prior to said coiling with a compression ratio between 6-12.
8. The process according to claim 1 , further comprising arranging the form-stable coiled collagen carrier in an inner container.
9. The process according to claim 8 , further comprising closing the inner container by applying a cover to the inner container.
10. The process according to claim 9 , further comprising arranging the inner container in an outer container, and sealing the outer container.
11. The process according to claim 10 , wherein the arranging of the form-stable coiled collagen carrier in the inner container and closing inner container is performed in a primary production room and the arranging of the inner container in an outer container is performed in a secondary production room, the first and the secondary production room being connected with each other by an airlock and the closed inner container being transported from the first to the second room via the airlock.
12. The process according to claim 1 , further comprising sterilizing the coiled collagen carrier.
13. The process according to claim 1 , wherein the process is carried out as an assembly-line process in which the collagen carrier is conveyed without intermediate storing between said humidifying and coiling and between said coiling and drying.