Topical compositions for pain relief, manufacture and use
The present invention relates to TRPV1 selective agonist compositions including a capsaicinoid, a surfactant and an extended release agent, and to methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.
1. A composition comprising:
i) 0.2-30% by weight of a capsaicinoid,
ii) 0.1-1.5% by weight of hyaluronic acid, wherein said hyaluronic acid comprises a mixture of low molecular weight hyaluronic acid and high molecular weight hyaluronic acid,
iii) 0.5-15% by weight nonionic surfactant, and
iv) lidocaine.
2. A composition as in claim 1 , wherein said capsaicinoid is capsaicin.
3. A composition as in claim 1 , wherein said capsaicinoid is trans-capsaicin or nonivamide.
4. A composition as in claim 1 , wherein said nonionic surfactant is PS 80.
5. A composition as in claim 1 , wherein said nonionic surfactant is polyoxy 40 hydrogenated castor oil.
6. A composition as in claim 1 further comprising a penetration enhancer.
7. A composition as in claim 6 , wherein said penetration enhancer is selected from the group consisting of DGME or propylene glycol.
8. A composition as in claim 1 further comprising an alcohol.
9. A composition as in claim 8 , wherein said alcohol is ethanol.
10. A composition as in claim 1 further comprising an analgesic or anesthetic agent.
11. A composition as in claim 10 , wherein said analgesic agent or anesthetic agent is selected from the group consisting of methyl salicylate, camphor, menthol, icilin, eucalyptol and phenol.
12. A composition as in claim 1 further comprising an anti-inflammatory agent.
13. A composition as in claim 12 , wherein said anti-inflammatory agent is selected from the group consisting of a flavonoid, a steroid, and an NSAID.
14. A composition as in claim 1 , wherein the composition is a liquid solution.
15. A composition as in claim 1 further comprising phenol.
16. A kit comprising:
i) a composition as in claim 1 , and
ii) a non occlusive applicator device.
17. A kit as in claim 16 further comprising a cleaning solution for removal of residual capsaicinoid.
18. A composition as in claim 1 comprising 1-20% by weight of capsaicinoid.
19. A composition as in claim 1 , wherein the low molecular weight hyaluronic acid has a molecular weight less than 200 Daltons, and the high molecular weight hyaluronic acid has a molecular weight greater than 800 kDaltons.
20. A composition as in claim 1 , wherein the molecular weight of hyaluronic acid ranges from 3 Daltons to 1,000 kDaltons.
21. A composition comprising:
i) 0.2-30% by weight of capsaicinoid,
ii) 0.1-1.5% by weight of hyaluronic acid,
iii) 0.5-15% by weight nonionic surfactant, and
iv) lidocaine.
22. A composition as in claim 21 , wherein said capsaicinoid is capsaicin.
23. A composition as in claim 21 , wherein said capsaicinoid is trans-capsaicin or nonivamide.
24. A composition as in claim 21 , wherein said nonionic surfactant is PS 80.
25. A composition as in claim 21 , wherein said nonionic surfactant is polyoxy 40 hydrogenated castor oil.
26. A composition as in claim 21 further comprising a penetration enhancer.
27. A composition as in claim 26 , wherein said penetration enhancer is selected from the group consisting of DGME or propylene glycol.
28. A composition as in claim 21 further comprising an alcohol.
29. A composition as in claim 28 , wherein said alcohol is ethanol.
30. A composition as in claim 21 further comprising an analgesic or anesthetic agent.
31. A composition as in claim 30 , wherein said analgesic agent or anesthetic agent is selected from the group consisting of methyl salicylate, camphor, menthol, icilin, eucalyptol and phenol.
32. A composition as in claim 21 further comprising an anti-inflammatory agent.
33. A composition as in claim 32 , wherein said anti-inflammatory agent is selected from the group consisting of a flavonoid, a steroid, and an NSAID.
34. A composition as in claim 21 , wherein the composition is a liquid solution.
35. A composition as in claim 21 further comprising phenol.
36. A kit comprising:
i) a composition as in claim 21 , and
ii) a non occlusive applicator device.
37. A kit as in claim 36 further comprising a cleaning solution for removal of residual capsaicinoid.
38. A composition as in claim 21 comprising 1-20% by weight of capsaicinoid.
39. A composition as in claim 21 , wherein the molecular weight of hyaluronic acid ranges from 3 kDaltons to 1,000 kDaltons.
40. A composition comprising:
i) 0.2-30% by weight of a capsaicinoid,
ii) 0.1-1.5% by weight hyaluronic acid,
iii) 2-15% by weight PS 80 or polyoxy 40 hydrogenated castor oil,
iv) 1-40% by weight penetration enhancer, and
v) lidocaine.
41. A composition as in claim 40 , wherein said capsaicinoid is capsaicin.
42. A composition as in claim 40 , wherein said capsaicinoid is trans-capsaicin or nonivamide.
43. A composition as in claim 40 , wherein said hyaluronic acid comprises a mixture of low molecular weight hyaluronic acid and high molecular weight hyaluronic acid.
44. A composition as in claim 43 , wherein the low molecular weight hyaluronic acid has a molecular weight less than 200 kDaltons, and the high molecular weight hyaluronic acid has a molecular weight greater than 800 kDaltons.
45. A composition as in claim 40 , wherein the composition comprises 2-15% by weight PS 80.
46. A composition as in claim 40 , wherein the composition comprises 2-15% by weight polyoxy 40 hydrogenated castor oil.
47. A composition as in claim 40 , wherein said penetration enhancer is selected from the group consisting of DGME or propylene glycol.
48. A composition as in claim 40 further comprising an alcohol.
49. A composition as in claim 48 , wherein said alcohol is ethanol.
50. A composition as in claim 40 further comprising an analgesic or anesthetic agent.
51. A composition as in claim 50 , wherein said analgesic agent or anesthetic agent is selected from the group consisting of methyl salicylate, camphor, menthol, icilin, eucalyptol and phenol.
52. A composition as in claim 40 further comprising an anti-inflammatory agent.
53. A composition as in claim 52 , wherein said anti-inflammatory agent is selected from the group consisting of a flavonoid, a steroid, and an NSAID.
54. A composition as in claim 40 , wherein the composition is a liquid solution.
55. A composition as in claim 40 further comprising phenol.
56. A kit comprising:
i) a composition as in claim 40 , and
ii) a non occlusive applicator device.
57. A kit as in claim 56 further comprising a cleaning solution for removal of residual capsaicinoid.
58. A composition as in claim 40 comprising 1-20% by weight of capsaicinoid.
59. A composition as in claim 40 , wherein the molecular weight of hyaluronic acid ranges from 3 kDaltons to 1,000 kDaltons.
60. A composition comprising:
i) 0.2-30% by weight of a capsaicinoid,
ii) 0.1-1.5% by weight hyaluronic acid,
iii) 2-15% by weight PS 80 or polyoxy 40 hydrogenated castor oil,
iv) 1-40% by weight of one or more penetration enhancers selected from the group consisting of DGME and propylene glycol, and
v) lidocaine.
61. A composition as in claim 60 , wherein said capsaicinoid is capsaicin.
62. A composition as in claim 60 , wherein said capsaicinoid is trans-capsaicin or nonivamide.
63. A composition as in claim 60 , wherein said hyaluronic acid comprises a mixture of low molecular weight hyaluronic acid and high molecular weight hyaluronic acid.
64. A composition as in claim 63 , wherein the low molecular weight hyaluronic acid has a molecular weight less than 200 kDaltons, and the high molecular weight hyaluronic acid has a molecular weight greater than 800 kDaltons.
65. A composition as in claim 60 , wherein the composition comprises 2-15% by weight PS 80.
66. A composition as in claim 60 , wherein the composition comprises 2-15% by weight polyoxy 40 hydrogenated castor oil.
67. A composition as in claim 60 , wherein said penetration enhancer is selected from the group consisting of DGME or propylene glycol.
68. A composition as in claim 60 further comprising an alcohol.
69. A composition as in claim 68 , wherein said alcohol is ethanol.
70. A composition as in claim 60 further comprising an analgesic or anesthetic agent.
71. A composition as in claim 70 , wherein said analgesic agent or anesthetic agent is selected from the group consisting of methyl salicylate, camphor, menthol, icilin, eucalyptol and phenol.
72. A composition as in claim 60 further comprising an anti-inflammatory agent.
73. A composition as in claim 72 , wherein said anti-inflammatory agent is selected from the group consisting of a flavonoid, a steroid, and an MAID.
74. A composition as in claim 60 , wherein the composition is a liquid solution.
75. A composition as in claim 60 further comprising phenol.
76. A kit comprising:
i) a composition as in claim 60 , and
ii) a non occlusive applicator device.
77. A kit as in claim 76 further comprising a cleaning solution for removal of residual capsaicinoid.
78. A composition as in claim 60 comprising 1-20% by weight of capsaicinoid.
79. A composition as in claim 60 , wherein the molecular weight of hyaluronic acid ranges from 3 kDaltons to 1,000 kDaltons.